Institution
Spanish National Research Council
Government•Madrid, Spain•
About: Spanish National Research Council is a government organization based out in Madrid, Spain. It is known for research contribution in the topics: Population & Galaxy. The organization has 79563 authors who have published 220470 publications receiving 7698991 citations. The organization is also known as: CSIC & Consejo Superior de Investigaciones Científicas.
Topics: Population, Galaxy, Catalysis, Stars, Gene
Papers published on a yearly basis
Papers
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TL;DR: RNA interference-mediated downregulation of deltaEF1 in cancer cells was sufficient to derepress E-cadherin expression and restore cell to cell adhesion, suggesting that deltaEF 1 is a key player in late stage carcinogenesis.
Abstract: Downregulation of E-cadherin is a crucial event for epithelial to mesenchymal transition (EMT) in embryonic development and cancer progression. Using the EpFosER mammary tumour model we show that during EMT, upregulation of the transcriptional regulator deltaEF1 coincided with transcriptional repression of E-cadherin. Ectopic expression of deltaEF1 in epithelial cells was sufficient to downregulate E-cadherin and to induce EMT. Analysis of E-cadherin promoter activity and chromatin immunoprecipitation identified deltaEF1 as direct transcriptional repressor of E-cadherin. In human cancer cells, transcript levels of deltaEF1 correlated directly with the extent of E-cadherin repression and loss of the epithelial phenotype. The protein was enriched in nuclei of human cancer cells and physically associated with the E-cadherin promoter. RNA interference-mediated downregulation of deltaEF1 in cancer cells was sufficient to derepress E-cadherin expression and restore cell to cell adhesion, suggesting that deltaEF1 is a key player in late stage carcinogenesis.
745 citations
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TL;DR: The activation of fly ash/slag pastes with NaOH solutions has been studied in this paper, where the authors established the equations of the models describing the mechanical behaviour of these pastes as a function of the factors and levels considered.
745 citations
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TL;DR: The emergence of epidemic clones harbouring several beta-lactamases simultaneously (ESBLs, metallo-beta-lacticamases or cephamycinases) and of new mechanisms of resistance to fluoroquinolones and aminoglycosides warrants future surveillance studies.
Abstract: Extended-spectrum beta-lactamases (ESBLs) have been increasingly reported in Europe since their first description in 1983 During the 1990s, they were described mainly as members of the TEM- and SHV-beta-lactamase families in Klebsiella pneumoniae causing nosocomial outbreaks Nowadays, they are mostly found in Escherichia coli that cause community-acquired infections and with increasing frequency contain CTX-M enzymes Dissemination of specific clones or clonal groups and epidemic plasmids in community and nosocomial settings has been the main reason for the increase in most of the widespread ESBLs belonging to the TEM (TEM-24, TEM-4, TEM-52), SHV (SHV-5, SHV-12) and CTX-M (CTX-M-9, CTX-M-3, CTX-M-14 or CTX-M-15) families in Europe Co-selection with other resistances, especially to fluoroquinolones, aminoglycosides and sulfonamides, seems to have contributed to the problem The emergence of epidemic clones harbouring several beta-lactamases simultaneously (ESBLs, metallo-beta-lactamases or cephamycinases) and of new mechanisms of resistance to fluoroquinolones and aminoglycosides warrants future surveillance studies
744 citations
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TL;DR: In this paper, the authors forecast an increase in temperature and a decrease in precipitation at the end of the 21st century, which will enhance stress on natural forests and shrubs, and will result in more water consumption, evapotranspiration, and probably interception.
744 citations
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TL;DR: In this article, a combination of volume thermal expansion (with and without an applied field), magnetic susceptibility and small-angle neutron scattering measurements was used to detect magnetic polarons above the ferromagnetic ordering temperature, Tc.
Abstract: Manganese perovskites based on the compound LaMnO3 are attracting considerable theoretical and technological interest by virtue of their unusual magnetic and electronic properties1–4. Most notable of these properties is the extremely large change in resistivity that accompanies the application of a magnetic field, an effect known as 'colossal' magnetoresistance. The origin of this effect has been attributed5–7 to the presence of magnetic polarons—charge carriers accompanied by a localized (and magnetically polarized) distortion of the surrounding crystal lattice8,9— but their existence and properties remains a matter of speculation. Here, using a combination of volume thermal expansion (with and without an applied field), magnetic susceptibility and small-angle neutron scattering measurements, we present evidence for the existence of magnetic polarons above the ferromagnetic ordering temperature, Tc. We detect the spontaneous formation of localized ∼12-A magnetic clusters above Tc which, on application of a magnetic field, grow in size but decrease in number. We argue that the response of these magnetic polarons to an applied magnetic field underlies the pronounced magnetoresistive properties in the compounds (La1–xAx)2/3Ca1/3MnO3 (where A is Y or Tb).
743 citations
Authors
Showing all 79686 results
Name | H-index | Papers | Citations |
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Guido Kroemer | 236 | 1404 | 246571 |
George Efstathiou | 187 | 637 | 156228 |
Peidong Yang | 183 | 562 | 144351 |
H. S. Chen | 179 | 2401 | 178529 |
David R. Williams | 178 | 2034 | 138789 |
Andrea Bocci | 172 | 2402 | 176461 |
Adrian L. Harris | 170 | 1084 | 120365 |
Gang Chen | 167 | 3372 | 149819 |
Gregory J. Hannon | 165 | 421 | 140456 |
Alvaro Pascual-Leone | 165 | 969 | 98251 |
Jorge E. Cortes | 163 | 2784 | 124154 |
Dongyuan Zhao | 160 | 872 | 106451 |
John B. Goodenough | 151 | 1064 | 113741 |
David D'Enterria | 150 | 1592 | 116210 |
A. Gomes | 150 | 1862 | 113951 |