Institution
Université de Sherbrooke
Education•Sherbrooke, Quebec, Canada•
About: Université de Sherbrooke is a education organization based out in Sherbrooke, Quebec, Canada. It is known for research contribution in the topics: Population & Receptor. The organization has 14922 authors who have published 28783 publications receiving 792511 citations. The organization is also known as: Universite de Sherbrooke & Sherbrooke University.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: In this paper, the authors proposed a new science of concrete, a science of admixtures and the use of sophisticated scientific apparatus to observe concrete microstructure and even nanostructure.
542 citations
••
TL;DR: The results were consistent with the polyneuropathy being due to the same mechanisms that are currently postulated to cause dysfunction in this syndrome of other organ systems (including the neuromuscular respiratory system).
536 citations
••
TL;DR: In this paper, the effect of temperature and particle volume concentration on the dynamic viscosity for the water-Al2O3 nanofluid has been experimentally investigated.
533 citations
••
Centre national de la recherche scientifique1, Joseph Fourier University2, Institut national de la recherche agronomique3, University of Coimbra4, Sewanee: The University of the South5, Stockholm University6, Hebrew University of Jerusalem7, University of Oldenburg8, Macaulay Institute9, Aristotle University of Thessaloniki10, Tel Aviv University11, Université de Sherbrooke12
TL;DR: This work shows the applicability of a set of protocols that can be widely applied to assess the impacts of global change drivers on species, communities and ecosystems.
531 citations
••
TL;DR: This review will focus on the relationship between aging, frailty and age-related diseases, and will highlight possible interventions to reduce the occurrence and effects of frailty in elderly people.
Abstract: The concept of frailty as a medically distinct syndrome has evolved based on the clinical experience of geriatricians and is clinically well recognizable. Frailty is a nonspecific state of vulnerability, which reflects multisystem physiological change. These changes underlying frailty do not always achieve disease status, so some people, usually very elderly, are frail without a specific life threatening illness. Current thinking is that not only physical but also psychological, cognitive and social factors contribute to this syndrome and need to be taken into account in its definition and treatment. Together, these signs and symptoms seem to reflect a reduced functional reserve and consequent decrease in adaptation (resilience) to any sort of stressor and perhaps even in the absence of extrinsic stressors. The overall consequence is that frail elderly are at higher risk for accelerated physical and cognitive decline, disability and death. All these characteristics associated with frailty can easily be applied to the definition and characterization of the aging process per se and there is little consensus in the literature concerning the physiological/biological pathways associated with or determining frailty. It is probably true to say that a consensus view would implicate heightened chronic systemic inflammation as a major contributor to frailty. This review will focus on the relationship between aging, frailty and age-related diseases, and will highlight possible interventions to reduce the occurrence and effects of frailty in elderly people.
528 citations
Authors
Showing all 15051 results
Name | H-index | Papers | Citations |
---|---|---|---|
Masashi Yanagisawa | 130 | 524 | 83631 |
Joseph V. Bonventre | 126 | 596 | 61009 |
Jeffrey L. Benovic | 99 | 264 | 30041 |
Alessio Fasano | 96 | 478 | 34580 |
Graham Pawelec | 89 | 572 | 27373 |
Simon C. Robson | 88 | 552 | 29808 |
Paul B. Corkum | 88 | 576 | 37200 |
Mario Leclerc | 88 | 374 | 35961 |
Stephen M. Collins | 86 | 320 | 25646 |
Ed Harlow | 86 | 190 | 61008 |
William D. Fraser | 85 | 827 | 30155 |
Jean Cadet | 83 | 372 | 24000 |
Vincent Giguère | 82 | 227 | 27481 |
Robert Gurny | 81 | 396 | 28391 |
Jean-Michel Gaillard | 81 | 410 | 26780 |