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Institution

University of Rochester

EducationRochester, New York, United States
About: University of Rochester is a education organization based out in Rochester, New York, United States. It is known for research contribution in the topics: Population & Laser. The organization has 63915 authors who have published 112762 publications receiving 5484122 citations. The organization is also known as: Rochester University.


Papers
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Journal ArticleDOI
TL;DR: In this paper, a new class of long-period fiber gratings that can be used as in-fiber, low-loss, band-rejection filters is presented.
Abstract: We present a new class of long-period fiber gratings that can be used as in-fiber, low-loss, band-rejection filters. Photoinduced periodic structures written in the core of standard communication-grade fibers couple light from the fundamental guided mode to forward propagating cladding modes and act as spectrally selective loss elements with insertion losses act as backreflections <-80 dB, polarization-mode-dispersions <0.01 ps and polarization-dependent-losses <0.02 dB.

1,696 citations

Book ChapterDOI
01 Aug 1993
TL;DR: An expectation-maximization (EM) algorithm for adjusting the parameters of the tree-structured architecture for supervised learning is presented and an online learning algorithm in which the parameters are updated incrementally is developed.
Abstract: We present a tree-structured architecture for supervised learning. The statistical model underlying the architecture is a hierarchical mixture model in which both the mixture coefficients and the mixture components are generalized linear models (GLIMs). Learning is treated as a maximum likelihood problem; in particular, we present an expectation-maximization (EM) algorithm for adjusting the parameters of the architecture. We also develop an online learning algorithm in which the parameters are updated incrementally. Comparative simulation results are presented in the robot dynamics domain.

1,689 citations

Journal ArticleDOI
TL;DR: A common receptor activation pathway can initiate innate immune responses to both bacterial and viral pathogens.
Abstract: The innate immune system contributes to the earliest phase of the host defense against foreign organisms and has both soluble and cellular pattern recognition receptors for microbial products. Two important members of this receptor group, CD14 and the Toll-like receptor (TLR) pattern recognition receptors, are essential for the innate immune response to components of Gram-negative and Gram-positive bacteria, mycobacteria, spirochetes and yeast. We now find that these receptors function in an antiviral response as well. The innate immune response to the fusion protein of an important respiratory pathogen of humans, respiratory syncytial virus (RSV), was mediated by TLR4 and CD14. RSV persisted longer in the lungs of infected TLR4-deficient mice compared to normal mice. Thus, a common receptor activation pathway can initiate innate immune responses to both bacterial and viral pathogens.

1,679 citations

Journal ArticleDOI
TL;DR: RSV infection is associated with substantial morbidity in U.S. children in both inpatient and outpatient settings, suggesting that control strategies targeting only high-risk children will have a limited effect on the total disease burden of RSV infection.
Abstract: Background The primary role of respiratory syncytial virus (RSV) in causing infant hospitalizations is well recognized, but the total burden of RSV infection among young children remains poorly defined Methods We conducted prospective, population-based surveillance of acute respiratory infections among children under 5 years of age in three US counties We enrolled hospitalized children from 2000 through 2004 and children presenting as outpatients in emergency departments and pediatric offices from 2002 through 2004 RSV was detected by culture and reverse-transcriptase polymerase chain reaction Clinical information was obtained from parents and medical records We calculated population-based rates of hospitalization associated with RSV infection and estimated the rates of RSV-associated outpatient visits Results Among 5067 children enrolled in the study, 919 (18%) had RSV infections Overall, RSV was associated with 20% of hospitalizations, 18% of emergency department visits, and 15% of office visit

1,678 citations

Journal ArticleDOI
TL;DR: In this paper, a non-cooperative equilibrium concept for super games is presented, which fits John Nash's noncooperative solution and also has some features resembling the Nash cooperative solution.
Abstract: Presents a non-cooperative equilibrium concept, applicable to supergames, which fits John Nash's non-cooperative equilibrium and also has some features resembling the Nash cooperative solution. Description of an ordinary game; Definition and discussion of a non-cooperative equilibrium for supergames; Description of supergame and supergame strategies; Information on the Cournot strategy.

1,672 citations


Authors

Showing all 64186 results

NameH-indexPapersCitations
Eugene Braunwald2301711264576
Cyrus Cooper2041869206782
Eric J. Topol1931373151025
Dennis W. Dickson1911243148488
Scott M. Grundy187841231821
John C. Morris1831441168413
Ronald C. Petersen1781091153067
David R. Williams1782034138789
John Hardy1771178171694
Russel J. Reiter1691646121010
Michael Snyder169840130225
Jiawei Han1681233143427
Gang Chen1673372149819
Marc A. Pfeffer166765133043
Salvador Moncada164495138030
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023101
2022383
20213,841
20203,895
20193,699
20183,541