University of Rochester

About: University of Rochester is a education organization based out in Rochester, New York, United States. It is known for research contribution in the topics: Population & Laser. The organization has 63915 authors who have published 112762 publications receiving 5484122 citations. The organization is also known as: Rochester University.

Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells

Abstract: background Patients with follicular lymphoma may survive for periods of less than 1 year to more than 20 years after diagnosis. We used gene-expression profiles of tumor-biopsy specimens obtained at diagnosis to develop a molecular predictor of the length of survival. methods Gene-expression profiling was performed on 191 biopsy specimens obtained from patients with untreated follicular lymphoma. Supervised methods were used to discover expression patterns associated with the length of survival in a training set of 95 specimens. A molecular predictor of survival was constructed from these genes and validated in an independent test set of 96 specimens. results Individual genes that predicted the length of survival were grouped into gene-expression signatures on the basis of their expression in the training set, and two such signatures were used to construct a survival predictor. The two signatures allowed patients with specimens in the test set to be divided into four quartiles with widely disparate median lengths of survival (13.6, 11.1, 10.8, and 3.9 years), independently of clinical prognostic variables. Flow cytometry showed that these signatures reflected gene expression by nonmalignant tumor-infiltrating immune cells. conclusions The length of survival among patients with follicular lymphoma correlates with the molecular features of nonmalignant immune cells present in the tumor at diagnosis.

2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia

Abstract: DINESH KHANNA, JOHN D. FITZGERALD, PUJA P. KHANNA, SANGMEE BAE, MANJIT K. SINGH, TUHINA NEOGI, MICHAEL H. PILLINGER, JOAN MERILL, SUSAN LEE, SHRADDHA PRAKASH, MARIAN KALDAS, MANEESH GOGIA, FERNANDO PEREZ-RUIZ, WILL TAYLOR, FREDERIC LIOTE, HYON CHOI, JASVINDER A. SINGH, NICOLA DALBETH, SANFORD KAPLAN, VANDANA NIYYAR, DANIELLE JONES, STEVEN A. YAROWS, BLAKE ROESSLER, GAIL KERR, CHARLES KING, GERALD LEVY, DANIEL E. FURST, N. LAWRENCE EDWARDS, BRIAN MANDELL, H. RALPH SCHUMACHER, MARK ROBBINS, NEIL WENGER, AND ROBERT TERKELTAUB

Improved Age Estimation for Solar-Type Dwarfs Using Activity-Rotation Diagnostics

Abstract: While the strong anticorrelation between chromospheric activity and age has led to the common use of the Ca II H and K emission index (R'_(HK) = L_(HK)/L_(bol)) as an empirical age estimator for solar-type dwarfs, existing activity-age relations produce implausible ages at both high and low activity levels.We have compiled R'_(HK) HK data from the literature for young stellar clusters, richly populating for the first time the young end of the activity-age relation. Combining the cluster activity data with modern cluster age estimates and analyzing the color dependence of the chromospheric activity age index,we derive an improved activity-age calibration for F7-K2 dwarfs (0:5 mag < B - V < 0.9 mag). We also present a more fundamentally motivated activity-age calibration that relies on conversion of R'_(HK) values through the Rossby number to rotation periods and then makes use of improved gyrochronology relations. We demonstrate that our new activity-age calibration has typical age precision of ~0.2 dex for normal solar-type dwarfs aged between the Hyades and the Sun (~0.6-4.5 Gyr). Inferring ages through activity-rotation-age relations accounts for some color-dependent effects and systematically improves the age estimates (albeit only slightly). We demonstrate that coronal activity as measured through the fractional X-ray luminosity (R_X = L_X/L_(bol)) has nearly the same age- and rotation inferring capability as chromospheric activity measured through R'_(HK). As a first application of our calibrations, we provide new activity-derived age estimates for a volume-limited sample of the 108 solar-type field dwarfs within 16 pc.

Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis

Abstract: BackgroundDupilumab, a human monoclonal antibody against interleukin-4 receptor alpha, inhibits signaling of interleukin-4 and interleukin-13, type 2 cytokines that may be important drivers of atopic or allergic diseases such as atopic dermatitis. MethodsIn two randomized, placebo-controlled, phase 3 trials of identical design (SOLO 1 and SOLO 2), we enrolled adults with moderate-to-severe atopic dermatitis whose disease was inadequately controlled by topical treatment. Patients were randomly assigned in a 1:1:1 ratio to receive, for 16 weeks, subcutaneous dupilumab (300 mg) or placebo weekly or the same dose of dupilumab every other week alternating with placebo. The primary outcome was the proportion of patients who had both a score of 0 or 1 (clear or almost clear) on the Investigator’s Global Assessment and a reduction of 2 points or more in that score from baseline at week 16. ResultsWe enrolled 671 patients in SOLO 1 and 708 in SOLO 2. In SOLO 1, the primary outcome occurred in 85 patients (38%) who...