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Institution

University of Turku

EducationTurku, Finland
About: University of Turku is a education organization based out in Turku, Finland. It is known for research contribution in the topics: Population & Galaxy. The organization has 16296 authors who have published 45124 publications receiving 1505428 citations. The organization is also known as: Turun yliopisto & Åbo universitet.


Papers
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Journal ArticleDOI
TL;DR: A sensor plasmid was constructed by inserting the regulation unit from the cadA determinant of plasmids pI258 to control the expression of firefly luciferase, capable of replicating in Gram-positive and Gram-negative bacteria.

239 citations

Journal ArticleDOI
TL;DR: In this article, a two-dimensional multi-component decomposition was presented for 122 early-type disc galaxies, using deep K s -band images, for which the results support the view that spiral galaxies with bulges brighter than -20 mag in the K band can evolve directly into S0s.
Abstract: Photometric scaling relations are studied for S0 galaxies and compared with those obtained for spirals. New two-dimensional multi-component decompositions are presented for 122 early-type disc galaxies, using deep K s -band images. Combining them with our previous decompositions, the final sample consists of 175 galaxies (Near-Infrared Survey of S0s, NIRSOS: 117 SOs + 22 S0/a and 36 Sa galaxies). As a comparison sample we use the Ohio State University Bright Spiral Galaxy Survey (OSUBSGS) of nearly 200 spirals, for which similar multi-component decompositions have previously been made by us. The improved statistics, deep images and the homogeneous decomposition method used allow us to re-evaluate the parameters of the bulges and discs. For spirals we largely confirm previous results, which are compared with those obtained for S0s. Our main results are as follows. (1) Important scaling relations are present, indicating that the formative processes of bulges and discs in S0s are coupled [e.g. M 0 K (disc) = 0.63 M 0 K (bulge) -9.3], as has been found previously for spirals [for OSUBSGS spirals M 0 K (disc) = 0.38 M 0 K (bulge) -15.5; the rms deviation from these relations is 0.5 mag for S0s and spirals]. (2) We obtain median r eff /h 0 r ~ 0.20, 0.15 and 0.10 for S0, S0/a-Sa and Sab-Sc galaxies, respectively: these values are smaller than predicted by simulation models in which bulges are formed by galaxy mergers. (3) The properties of bulges of S0s are different from the elliptical galaxies, which are manifested in the M 0 K (bulge) versus r eff relation, in the photometric plane (μ 0 , n, reff ), and to some extent also in the Kormendy relation (〈μ〉 eff versus r eff ). The bulges of S0s are similar to bulges of spirals with M 0 K (bulge) < -20 mag. Some S0s have small bulges, but their properties are not compatible with the idea that they could evolve to dwarfs by galaxy harassment. (4) The relative bulge flux (B/T) for S0s covers the full range found in the Hubble sequence, even with 13 per cent having B/T < 0.15, typical for late-type spirals. (5) The values and relations of the parameters of the discs [h 0 r , M 0 K (disc), μ 0 (0)] of the S0 galaxies in NIRS0S are similar to those obtained for spirals in the OSUBSGS. Overall, our results support the view that spiral galaxies with bulges brighter than -20 mag in the K band can evolve directly into S0s, due to stripping of gas followed by truncated star formation.

238 citations

Journal ArticleDOI
TL;DR: The results suggest that the open-plan office is not recommended for professional workers, and room acoustical descriptors showed a significant reduction in speech privacy after relocation.
Abstract: The aim was to determine how the perceived work environment, especially acoustic environment, and its effects differed in private office rooms and in open-plan offices. The subjects consisted of 31 workers who moved from private office rooms to open-plan offices and who answered the questionnaire before and after the relocation. Private office rooms were occupied only by one person while open-plan offices were occupied by more than 20 persons. Room acoustical descriptors showed a significant reduction in speech privacy after relocation. The noise level averaged over the whole work day did not change but the variability of noise level reduced significantly. Negative effects of acoustic environment increased significantly, including increased distraction, reduced privacy, increased concentration difficulties and increased use of coping strategies. Self-rated loss of work performance because of noise doubled. Cognitively demanding work and phone conversations were most distracted by noise. The benefits that are often associated with open-plan offices did not appear: cooperation became less pleasant and direct and information flow did not change. Nowadays, most office workers, independent of job type, are located in open-plan offices without the individual needs of privacy, concentration and interaction being analysed. This intervention study consisted of professional workers. Their work tasks mainly required individual efforts, and interaction between other workers was not of primary concern, although necessary. The results suggest that the open-plan office is not recommended for professional workers. Similar intervention studies should also be made for other job types.

238 citations

Journal ArticleDOI
TL;DR: Data indicate that transcription factor Stat3 is involved in metastatic behavior of human prostate cancer cells and may provide a therapeutic target to prevent metastatic spread of primary prostate cancer.
Abstract: There are currently no effective therapies for metastatic prostate cancer because the molecular mechanisms that underlie the metastatic spread of primary prostate cancer are unclear. Transcription factor Stat3 is constitutively active in malignant prostate epithelium, and its activation is associated with high histological grade and advanced cancer stage. In this work, we hypothesized that Stat3 stimulates metastatic progression of prostate cancer. We show that Stat3 is active in 77% of lymph node and 67% of bone metastases of clinical human prostate cancers. Importantly, adenoviral gene delivery of wild-type Stat3 (AdWTStat3) to DU145 human prostate cancer cells increased the number of lung metastases by 33-fold in an experimental metastasis assay compared with controls. Using various methods to inhibit Stat3, we demonstrated that Stat3 promotes human prostate cancer cell migration. Stat3 induced the formation of lamellipodia in both DU145 and PC-3 cells, further supporting the concept that Stat3 promotes a migratory phenotype of human prostate cancer cells. Moreover, Stat3 caused the rearrangement of cytoplasmic actin stress fibers and microtubules in both DU145 and PC-3 cells. Finally, inhibition of the Jak2 tyrosine kinase decreased both activation of Stat3 and prostate cancer cell motility. Collectively, these data indicate that transcription factor Stat3 is involved in metastatic behavior of human prostate cancer cells and may provide a therapeutic target to prevent metastatic spread of primary prostate cancer.

238 citations

Journal ArticleDOI
Peter A. R. Ade1, Nabila Aghanim2, Francisco Argüeso3, Monique Arnaud4  +305 moreInstitutions (77)
TL;DR: The Second Planck Catalogue of Compact Sources (PCCS2) as discussed by the authors is a list of discrete objects detected in single-frequency maps from the full duration of the Planck mission and supersedes previous versions.
Abstract: The Second Planck Catalogue of Compact Sources is a list of discrete objects detected in single-frequency maps from the full duration of the Planck mission and supersedes previous versions. It consists of compact sources, both Galactic and extragalactic, detected over the entire sky. Compact sources detected in the lower frequency channels are assigned to the PCCS2, while at higher frequencies they are assigned to one of two subcatalogues, the PCCS2 or PCCS2E, depending on their location on the sky. The first of these (PCCS2) covers most of the sky and allows the user to produce subsamples at higher reliabilities than the target 80% integral reliability of the catalogue. The second (PCCS2E) contains sources detected in sky regions where the diffuse emission makes it difficult to quantify the reliability of the detections. Both the PCCS2 and PCCS2E include polarization measurements, in the form of polarized flux densities, or upper limits, and orientation angles for all seven polarization-sensitive Planck channels. The improved data-processing of the full-mission maps and their reduced noise levels allow us to increase the number of objects in the catalogue, improving its completeness for the target 80% reliability as compared with the previous versions, the PCCS and the Early Release Compact Source Catalogue (ERCSC).

238 citations


Authors

Showing all 16461 results

NameH-indexPapersCitations
Kari Alitalo174817114231
Mika Kivimäki1661515141468
Jaakko Kaprio1631532126320
Veikko Salomaa162843135046
Markus W. Büchler148154593574
Eugene C. Butcher14644672849
Steven Williams144137586712
Terho Lehtimäki1421304106981
Olli T. Raitakari1421232103487
Pim Cuijpers13698269370
Jeroen J. Bax132130674992
Sten Orrenius13044757445
Aarno Palotie12971189975
Stefan W. Hell12757765937
Carlos López-Otín12649483933
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023102
2022290
20212,673
20202,688
20192,407
20182,189