University of Turku

About: University of Turku is a education organization based out in Turku, Finland. It is known for research contribution in the topics: Population & Galaxy. The organization has 16296 authors who have published 45124 publications receiving 1505428 citations. The organization is also known as: Turun yliopisto & Åbo universitet.

Periodontitis: A Multifaceted Disease of Tooth-Supporting Tissues.

Abstract: Periodontitis is an infection-driven inflammatory disease in which the composition of biofilms plays a significant role. Dental plaque accumulation at the gingival margin initiates an inflammatory response that, in turn, causes microbial alterations and may lead to drastic consequences in the periodontium of susceptible individuals. Chronic inflammation affects the gingiva and can proceed to periodontitis, which characteristically results in irreversible loss of attachment and alveolar bone. Periodontitis appears typically in adult-aged populations, but young individuals can also experience it and its harmful outcome. Advanced disease is the major cause of tooth loss in adults. In addition, periodontitis is associated with many chronic diseases and conditions affecting general health.

Cognitive impairment and the brain dopaminergic system in Parkinson disease: [18F]fluorodopa positron emission tomographic study.

Abstract: Objective To investigate the role of the brain dopaminergic system in cognitive impairment in patients with Parkinson disease (PD). Design We studied 28 patients with PD and 16 age-matched healthy control subjects using [ 18 F]fluorodopa (fluorodopa F 18) positron emission tomography. Patients with PD showed a variable degree of cognitive impairment, which was assessed using the Mini-Mental State Examination and detailed neuropsychologic assessment, including tests sensitive for frontal lobe function. Results [ 18 F]Fluorodopa uptake was reduced in the putamen (to 36% of the control mean; P P P 18 F]fluorodopa uptake values. The influx constant ( K i occ ) in the caudate nucleus had a negative association with performance in the attention-demanding Stroop interference task, especially with the interference time. The K i occ in the frontal cortex had a positive correlation with performance in the digit span (backwards), verbal fluency, and verbal immediate recall tests. Thus, the better the patient performed in tasks demanding immediate and working memory and executive strategies, the better the [ 18 F]fluorodopa uptake in the frontal cortex. In the putamen, no significant correlation was seen between the K i occ value and any of the cognitive tests. The severity of the motor symptoms of PD and [ 18 F]fluorodopa uptake showed a negative correlation in the putamen ( r = −0.38; P = .04), and in the caudate nucleus a similar trend was seen ( r = −0.36; P = .06). Conclusions Reduced [ 18 F]fluorodopa uptake in PD in the caudate nucleus (and frontal cortex) is related to impairment in neuropsychologic tests measuring verbal fluency, working memory, and attentional functioning reflecting frontal lobe function. This indicates that dysfunction of the dopamine system has an impact on the cognitive impairment of patients with PD. However, our results do not exclude the possibility of more generalized cognitive impairment in PD, the pathophysiology of which is probably different and more generalized.

The problem of generalizability: anecdotes and evidence in accounting research

Abstract: Generalization in accounting research is always suspect as the social context and institutions of accounting change over time and space. However, exactly for this reason, there are a number of different ways to reach pragmatic and somewhat generalizable results. No research programme or approach has an absolute upper hand in understanding the true dynamics of economic development. The genuine puzzle of inductive reasoning creates a rhetorical element for all attempts to generalize in accounting research. The main rhetorics used in accounting studies are statistical, contextual, and constructive generalization. To put it in broad terms, statistical generalization rhetoric relies on formal arguments brought from a mathematical theory, contextual generalization rhetoric is based on understanding of the historical and institutional context, and constructive generalization relies on the diffusion of innovation. Combining the often silenced opportunities of contextual or constructive generalization rhetorics in...

Clinical Expression of Leber Hereditary Optic Neuropathy Is Affected by the Mitochondrial DNA–Haplogroup Background

Abstract: Leber hereditary optic neuropathy (LHON) is due primarily to one of three common point mutations of mitochondrial DNA (mtDNA), but the incomplete penetrance implicates additional genetic or environmental factors in the pathophysiology of the disorder. Both the 11778G→A and 14484T→C LHON mutations are preferentially found on a specific mtDNA genetic background, but 3460G→A is not. However, there is no clear evidence that any background influences clinical penetrance in any of these mutations. By studying 3,613 subjects from 159 LHON-affected pedigrees, we show that the risk of visual failure is greater when the 11778G→A or 14484T→C mutations are present in specific subgroups of haplogroup J (J2 for 11778G→A and J1 for 14484T→C) and when the 3460G→A mutation is present in haplogroup K. By contrast, the risk of visual failure is significantly less when 11778G→A occurs in haplogroup H. Substitutions on MTCYB provide an explanation for these findings, which demonstrate that common genetic variants have a marked effect on the expression of an ostensibly monogenic mtDNA disorder.