Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
D. Forman,D. G. Newell,F. Fullerton,J. W. G. Y. Yarnell,A. R. Stacey,Nicholas J. Wald,Freddy Sitas +6 more
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TLDR
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.Abstract:
OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.read more
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Antihelicobacter Activity of a Flavonoid Compound Isolated from Desmostachya Bipinnata
TL;DR: In this paper, the potential in vitro antihelicobacter activity of selected Egyptian plants, focusing on the determination of the main component responsible for such activity, was investigated, where the main objective is to obtain a natural product have anti-hemorrhobacterial activity.
Journal ArticleDOI
Epidemiological aspects of Helicobacter pylori infection in childhood and adolescence
TL;DR: It was noted that Helicobacter pylori infection is mainly acquired during childhood, age-related prevalence, main risk factors are associated to low socioeconomic status, and its transmission mechanism remains unclear.
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Role of Helicobacter pylori infection in the incidence and clinical course of monoclonal gammopathy of undetermined significance
TL;DR: Role of helicobacter pylori infection in the incidence and clinical course of monoclonal gammopathy of undetermined significance is investigated.
Journal ArticleDOI
Helicobacter pylori eradication and metachronous gastric cancer after endoscopic mucosal resection of early gastric cancer
Soichi Nakagawa,Masahiro Asaka,Masako Kato,T. Nakamura,Chieko Kato,Toshio Fujioka,Masaharu Tatsuta,K. Keida,Shuichi Terao,Shin Ichi Takahashi,Naomi Uemura,T. Kato,Nobuo Aoyama,D. Saito,Masayuki Suzuki,A. Imamura,K. Sato,Hiroto Miwa,H. Nomura,M. Kaise,S. Oohara,Takashi Kawai,K. Urabe,Nobuhiro Sakaki,Susumu Ito,Y. Noda,Akinori Yanaka,Kazuo Kusugami,Hidemi Goto,Takahisa Furuta,M. Fujino,F. Kinjyou,T. Ookusa +32 more
TL;DR: Although longer term, prospective randomized controlled trials are needed to better estimate the extent and sustainability of possible benefits, this study suggests that the eradicated H. pylori may help reduce the incidence of metachronous gastric cancer.
Book ChapterDOI
Dietary salt, high blood pressure and other harmful effects on health.
F.J. He,G.A. MacGregor +1 more
TL;DR: This chapter reviews the evidence that relates salt to raised blood pressure as well as the possible mechanisms whereby salt increases blood pressure and briefly discusses other harmful effects of salt on health.
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Journal Article
Statistical methods in cancer research. Volume I - The analysis of case-control studies.
N. E. Breslow,N. E. Day +1 more
Statistical methods in cancer research. Vol. 1. The analysis of case-control studies.
N. E. Breslow,N. E. Day +1 more
TL;DR: Case-control studies have come into increasing favour, and they are now one of the commonest forms of epidemiol-ogical studies.
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The decline in gastric cancer: epidemiology of an unplanned triumph
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Geographic association of Helicobacter pylori antibody prevalence and gastric cancer mortality in rural China.
D. Forman,Freddy Sitas,D. G. Newell,A. R. Stacey,J Boreham,Richard Peto,T. C. Campbell,J. Li,Junshi Chen +8 more
TL;DR: In this article, the prevalence of IgG antibodies to H. pylori in plasma samples taken in 1983 from 1882 men, aged 35-64 years, in 46 rural counties of the People's Republic of China.
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Low serum-vitamin-A and subsequent risk of cancer. Preliminary results of a prospective study.
TL;DR: Results suggest that measures taken to increase serum-retinol levels in man may lead to a reduction in cancer risk.