Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
D. Forman,D. G. Newell,F. Fullerton,J. W. G. Y. Yarnell,A. R. Stacey,Nicholas J. Wald,Freddy Sitas +6 more
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TLDR
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.Abstract:
OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.read more
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Helicobacter pylori Infection in Elderly People (Does Quantitative Serological Testing Predict Gastroduodenal Ulcer Disease
TL;DR: The results indicate that the magnitude of H. pylori IgG serology cannot be used to predict the presence or absence of peptic ulcer disease in the elderly.
Book ChapterDOI
Gastric Cancer: Epidemiology of gastric cancer
Mark E. Lockhart,Cheri L. Canon +1 more
TL;DR: In this chapter, the epidemiologic factors of gastric cancer, including its incidence, mortality, pathogenesis, and risk factors, are discussed.
Journal ArticleDOI
Proliferating cell nuclear antigen (PCNA) immunostaining in Helicobacter pylori infection: impact of eradication.
Theodore Rokkas,Christos Liatsos,Andreas Karameris,Evangeija Petridou,Andreas C. Lazaris,Dimitris Antoniades,Evangeios Kalafatis +6 more
TL;DR: It is concluded that H. pylori infection alters the replication cycle of the gastric mucosa inducing hyperproliferation, which return towards normal after successful H.pylori eradication.
Journal ArticleDOI
Gastric Abnormalities in Humoral Immune Deficiency Syndromes
TL;DR: Regular endoscopic screening is warranted in patients with late-onset hypogammaglobulinaemia as there is no evidence to support a role of Helicobacter pylori infection in the aetiopathology of these gastric abnormalities.
Journal ArticleDOI
Serological response to Helicobacter pylori in gastric and non-gastric cancer.
M Menegatti,Dino Vaira,John Holton,Fernanda Miranda,Chiara Ricci,Riccardo Gusmaroli,Colin Ainley,Mario Miglioli,Luigi Barbara +8 more
TL;DR: Serological immune response to H. pylori in gastric cancer, non-gastric cancer and outpatients seems different both quantitatively and qualitatively; serology was more reliable than histology in detection of H. Pylori.
References
More filters
Journal Article
Statistical methods in cancer research. Volume I - The analysis of case-control studies.
N. E. Breslow,N. E. Day +1 more
Statistical methods in cancer research. Vol. 1. The analysis of case-control studies.
N. E. Breslow,N. E. Day +1 more
TL;DR: Case-control studies have come into increasing favour, and they are now one of the commonest forms of epidemiol-ogical studies.
Journal ArticleDOI
The decline in gastric cancer: epidemiology of an unplanned triumph
Journal ArticleDOI
Geographic association of Helicobacter pylori antibody prevalence and gastric cancer mortality in rural China.
D. Forman,Freddy Sitas,D. G. Newell,A. R. Stacey,J Boreham,Richard Peto,T. C. Campbell,J. Li,Junshi Chen +8 more
TL;DR: In this article, the prevalence of IgG antibodies to H. pylori in plasma samples taken in 1983 from 1882 men, aged 35-64 years, in 46 rural counties of the People's Republic of China.
Journal ArticleDOI
Low serum-vitamin-A and subsequent risk of cancer. Preliminary results of a prospective study.
TL;DR: Results suggest that measures taken to increase serum-retinol levels in man may lead to a reduction in cancer risk.