Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
D. Forman,D. G. Newell,F. Fullerton,J. W. G. Y. Yarnell,A. R. Stacey,Nicholas J. Wald,Freddy Sitas +6 more
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TLDR
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.Abstract:
OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.read more
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Prevalence of H pylori associated ‘high risk gastritis’ for development of gastric cancer in patients with normal endoscopic findings
Andreas Leodolter,Matthias P. Ebert,Ulrich Peitz,K. Wolle,Stefan Kahl,Michael Vieth,Peter Malfertheiner +6 more
TL;DR: The age-dependent increase in prevalence of severe histopathological changes in gastric mucosa does not allow estimating the individual risk for gastric cancer development--only a proper follow-up can provide this information.
Journal ArticleDOI
Immunohistochemical detection of 8-hydroxydeoxyguanosine, a marker of oxidative DNA damage, in human chronic cholecystitis
Shuichi Seki,Takuya Kitada,Takao Yamada,Hiroki Sakaguchi,Kazuki Nakatani,Naoyoshi Onoda,Katsusuke Satake +6 more
TL;DR: Immunohistochemical detection of 8‐hydroxydeoxyguanosine, a marker of oxidative DNA damage, in human chronic cholecystitis is detected.
Journal ArticleDOI
The best method of detecting prior Helicobacter pylori infection.
Chien-Yu Lu,Chao-Hung Kuo,Yi-Ching Lo,Hung-Yi Chuang,Yuan-Chieh Yang,I-Chen Wu,Fang-Jong Yu,Yi-Chen Lee,Chang-Ming Jan,Wen-Ming Wang,Deng-Chyang Wu +10 more
TL;DR: Helico Blot 2.1 can detect past H pylori infections for up to 4 years, and is the best method to date for detecting previous long-term H pylonori infection.
Journal ArticleDOI
p53 expression in gastric mucosa with Helicobacter pylori infection.
Masaaki Kodama,Toshio Fujioka,Kodama R,Kenji Takahashi,Toshihiro Kubota,Kazunari Murakami,Masaru Nasu +6 more
TL;DR: The results suggest that p53 alterations occur in the H. pylori‐infected gastric mucosa and that H.pylori infection may play an important role in gastric carcinogenesis.
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Association of Helicobacter pylori with gastroduodenal diseases.
TL;DR: H. pylori is now recognized as a causative agent of gastritis and peptic ulcers and is considered to be related to the development of gastric mucosa-associated lymphoid tissue (MALT) lymphoma, especially those of low grade.
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TL;DR: In this article, the prevalence of IgG antibodies to H. pylori in plasma samples taken in 1983 from 1882 men, aged 35-64 years, in 46 rural counties of the People's Republic of China.
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