Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
D. Forman,D. G. Newell,F. Fullerton,J. W. G. Y. Yarnell,A. R. Stacey,Nicholas J. Wald,Freddy Sitas +6 more
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TLDR
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.Abstract:
OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.read more
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Effect of early eradication on Helicobacter pylori-related gastric carcinogenesis in Mongolian gerbils.
Koji Nozaki,Nobuyuki Shimizu,Yuzuru Ikehara,Manami Inoue,Tetsuya Tsukamoto,Ken Ichi Inada,Harunari Tanaka,Toshiko Kumagai,Michio Kaminishi,Masae Tatematsu +9 more
TL;DR: Hp infection strongly enhanced gastric carcinogenesis initiated with a chemical carcinogen, and following eradication at an early period this enhancing effect was effectively reduced.
Journal ArticleDOI
Relationship between Helicobacter pylori infection and smoking and drinking habits
Atsushi Ogihara,Shogo Kikuchi,Ayako Hasegawa,Michiko Kurosawa,Kazumasa Miki,Eizo Kaneko,Hiroshi Mizukoshi +6 more
TL;DR: These relationships were investigated by collecting sera and information from 8837 subjects by investigating the relationship between H. pylori infection and smoking or drinking habits and finding conflicting results.
Journal ArticleDOI
Eradication of Helicobacter pylori prevents cancer development in subjects with mild gastric atrophy identified by serum pepsinogen levels.
Kimihiko Yanaoka,Masashi Oka,Hiroshi Ohata,Noriko Yoshimura,Hisanobu Deguchi,Chizu Mukoubayashi,Shotaro Enomoto,Izumi Inoue,Mikitaka Iguchi,Takao Maekita,Kazuki Ueda,Hirotoshi Utsunomiya,Hideyuki Tamai,Mitsuhiro Fujishiro,Masataka Iwane,Tatsuya Takeshita,Osamu Mohara,Masao Ichinose +17 more
TL;DR: It is strongly indicated that cancer development after eradication depends on the presence of extensive CAG before eradication and that H. pylori eradication is beneficial to most PG test‐negative subjects with mild CAG as defined by the aforementioned criteria.
Reference EntryDOI
Helicobacter pylori eradication for the prevention of gastric neoplasia
TL;DR: Limited, moderate-quality evidence is found that searching for and eradicating H. pylori reduces the incidence of gastric cancer in healthy asymptomatic infected Asian individuals, but it is not possible to extrapolate this data to other populations.
Journal ArticleDOI
Helicobacter pylori Infection and Gastric Cancer A Nested Case± Control Study in a Rural Area of Japan
Yoshiyuki Watanabe,John H. Kurata,Shigeto Mizuno,Masako Mukai,Hideto Inokuchi,Kazumasa Miki,Kotaro Ozasa,Keiichi Kawai +7 more
TL;DR: Results suggest that Helicobacter pylori infection alone is not directly associated with gastriccarcinogenesis but has an indirect relation to gastriccancer through the development of atrophic gastritis.
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D. Forman,Freddy Sitas,D. G. Newell,A. R. Stacey,J Boreham,Richard Peto,T. C. Campbell,J. Li,Junshi Chen +8 more
TL;DR: In this article, the prevalence of IgG antibodies to H. pylori in plasma samples taken in 1983 from 1882 men, aged 35-64 years, in 46 rural counties of the People's Republic of China.
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Low serum-vitamin-A and subsequent risk of cancer. Preliminary results of a prospective study.
TL;DR: Results suggest that measures taken to increase serum-retinol levels in man may lead to a reduction in cancer risk.