Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
D. Forman,D. G. Newell,F. Fullerton,J. W. G. Y. Yarnell,A. R. Stacey,Nicholas J. Wald,Freddy Sitas +6 more
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TLDR
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.Abstract:
OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.read more
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Role of Helicobacter pylori CagA+ strains and risk of adenocarcinoma of the stomach and esophagus.
Anna H. Wu,Jean E. Crabtree,Leslie Bernstein,Peter Hawtin,Myles Cockburn,Chiu-chen Tseng,David Forman +6 more
TL;DR: There is no evidence that infection with CagA+ strains of H. pylori reduces risk of esophageal and gastric cardia adenocarcinoma in this population, and the positive association between risk of distal gastric cancer and infection with H. Pylori is confirmed.
Journal ArticleDOI
Epidemiology of Helicobacter pylori infection among 4742 randomly selected subjects from Northern Ireland.
TL;DR: This study demonstrated a high prevalence of infection in a population from a developed country and previously reported associations between H. pylori infection, age, sex, social class, and reduced height in females were confirmed and smoking was identified as a possible risk factor.
Journal ArticleDOI
Randomised trial of endoscopy with testing for Helicobacter pylori compared with non-invasive H pylori testing alone in the management of dyspepsia
Kenneth E.L. McColl,Lilian S. Murray,Derek Gillen,Andrew Walker,A Wirz,Jonathan A. Fletcher,C Mowat,E Henry,Andrew W. Kelman,A. Dickson +9 more
TL;DR: In patients less than 55 years of age with uncomplicated dyspepsia, non-invasive testing for H pylori is as effective and as safe as endoscopy and is less uncomfortable and distressing for the patient.
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Helicobacter pylori causes Hyperproliferation of the gastric Epithelium: Pre- and Post-Eradication indices of proliferating cell nuclear antigen
F. Brenes,Bernardo Ruiz,Pelayo Correa,Fred Hunter,Thiruvengadam Rhamakrishnan,Elizabeth T. H. Fontham,Tei-Ying Shi +6 more
TL;DR: The results indicate that the gastric mucosa infected with HP is in a state of hyperproliferation, reflected in the reduction in number of polymorphonuclear and mononuclear cell infiltrates, and a reduction in the amount of superficial mucosa damage.
Journal ArticleDOI
Antrum- and corpus mucosa-infiltrating CD4(+) lymphocytes in Helicobacter pylori gastritis display a Th1 phenotype.
Frank Sommer,Gerhard Faller,Peter C. Konturek,Thomas Kirchner,Eckhart G. Hahn,Jürgen Zeus,Martin Röllinghoff,Michael Lohoff +7 more
TL;DR: CD4+ cells infiltrating antrum and corpus stomach mucosa during H. pylori infection show a Th1 phenotype, and this polarized Th1-type response may contribute to the inability of the immune system to eradicate the bacterium.
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