Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
D. Forman,D. G. Newell,F. Fullerton,J. W. G. Y. Yarnell,A. R. Stacey,Nicholas J. Wald,Freddy Sitas +6 more
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TLDR
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.Abstract:
OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.read more
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9 Helicobacter pylori as a risk factor for cancer
Penelope M. Webb,David Forman +1 more
TL;DR: Prevention and treatment of infection are possible approaches to reducing gastric cancer rates and, to date, anti-Helicobacter therapy has only been shown to be of potential benefit in the treatment of low grade gastric MALT lymphomas.
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A new mutation of E-cadherin gene in familial gastric linitis plastica cancer with extra-digestive dissemination.
Laurence Dussaulx-Garin,Blayau M,Mael Pagenault,Le Berre-Heresbach N,Jean-Luc Raoul,Jean-Pierre Campion,David,Jean-François Bretagne +7 more
TL;DR: In three patients diagnosed with poorly differentiated infiltrative independent-cell gastric adenocarcinoma, polymerase chain reaction-sequencing of the E-cadherin gene of white blood cells identified a heterozygous nonsense mutation of exon 3, producing a stop codon at position 95 (Q95X), resulting in a truncated protein.
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Bacteria in the aetio-pathogenesis of gastric cancer: a review.
TL;DR: The association of H. pylori with gastric carcinoma is mainly based on circumstantial evidence: epidemiological studies indicate a moderately increased risk for gastric cancer in H.pylori-positive subjects compared with H.P. plyori-negative; recent follow-up studies show a significant development of atrophic gastritis in H.'s pyloris-positive patients.
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High-performance liquid chromatography for quantification of plumbagin, an anti-Helicobacter pylori compound of Plumbago zeylanica L.
Yuan-Chuen Wang,Tung-Liang Huang +1 more
TL;DR: A reversed-phase high-performance liquid chromatography (HPLC) method is developed and observed that plumbagin has strong anti-H.
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Defining the pathologic diagnosis of metaplasia, atrophy, dysplasia, and gastric adenocarcinoma.
TL;DR: The histopathologic steps that predate the development of gastric cancer and the risks of transformation that they confer are reviewed to better identify the patients at risk and to implement preventive strategies.
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Geographic association of Helicobacter pylori antibody prevalence and gastric cancer mortality in rural China.
D. Forman,Freddy Sitas,D. G. Newell,A. R. Stacey,J Boreham,Richard Peto,T. C. Campbell,J. Li,Junshi Chen +8 more
TL;DR: In this article, the prevalence of IgG antibodies to H. pylori in plasma samples taken in 1983 from 1882 men, aged 35-64 years, in 46 rural counties of the People's Republic of China.
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Low serum-vitamin-A and subsequent risk of cancer. Preliminary results of a prospective study.
TL;DR: Results suggest that measures taken to increase serum-retinol levels in man may lead to a reduction in cancer risk.