Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
D. Forman,D. G. Newell,F. Fullerton,J. W. G. Y. Yarnell,A. R. Stacey,Nicholas J. Wald,Freddy Sitas +6 more
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TLDR
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.Abstract:
OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.read more
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Differentiation between isolates of Helicobacter pylori by PCR-RFLP analysis of urease A and B genes and comparison with ribosomal RNA gene patterns
TL;DR: Diversity amongst H. pylori was demonstrated and PCR analysis of urease genes provided a novel method of identifying isolates and the profiles were reproducible and convenient to obtain and analyse, and were almost as discriminatory as HaeIII ribopatterns.
Journal ArticleDOI
Helicobacter pylori Activates NF-κB via the Alternative Pathway in B Lymphocytes
Tomoya Ohmae,Yoshihiro Hirata,Shin Maeda,Wataru Shibata,Ayako Yanai,Keiji Ogura,Haruhiko Yoshida,Takao Kawabe,Masao Omata +8 more
TL;DR: H. pylori-induced processing of NF-κB2/p100 to p52 may drive lymphocytes to acquire malignant potential and the effects on chemokine production and antiapoptosis mediated by H. pylonori are investigated.
Journal ArticleDOI
Proliferation and apoptosis in gastric antral epithelial cells of patients infected with Helicobacter pylori.
Tae Jung Jang,Jung Ran Kim +1 more
TL;DR: Cell proliferation was significantly lower in Gastric cancers than in gastric ulcers, but the apoptotic count did not show a significant differenence between these diseases, which is thought to be closely related to the relatively decreased acute inflammation.
Journal ArticleDOI
Effect of Helicobacter pylori-Induced Cyclooxygenase-2 on Gastric Epithelial Cell Kinetics: Implication for Gastric Carcinogenesis
Casmir Wambura,Nobuo Aoyama,Daisuke Shirasaka,Toshiyuki Sakai,Takahiro Ikemura,Masanori Sakashita,Shuji Maekawa,Kohei Kuroda,Takashi Inoue,Shigeyuki Ebara,Masaki Miyamoto,Masato Kasuga +11 more
TL;DR: This data indicates that suppression of Cyclooxygenase (COX)‐2 induced by Helicobacter pylori is thought to enhance gastric carcinogenesis by affecting the maintenance of epithelial homeostasis.
Journal ArticleDOI
Snail is an independent prognostic predictor for progression and patient survival of gastric cancer.
Hongyong He,Weidong Chen,Xuefei Wang,Cong Wang,Fenglin Liu,Zhenbin Shen,Jiejie Xu,Jianxin Gu,Yihong Sun +8 more
TL;DR: The data suggest that Snail expression could be a reliable independent prognostic factor to predict gastric carcinoma progression, which might open a new avenue for potential clinical intervention with functional Snails expression in gastric cancer patients.
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D. Forman,Freddy Sitas,D. G. Newell,A. R. Stacey,J Boreham,Richard Peto,T. C. Campbell,J. Li,Junshi Chen +8 more
TL;DR: In this article, the prevalence of IgG antibodies to H. pylori in plasma samples taken in 1983 from 1882 men, aged 35-64 years, in 46 rural counties of the People's Republic of China.
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Low serum-vitamin-A and subsequent risk of cancer. Preliminary results of a prospective study.
TL;DR: Results suggest that measures taken to increase serum-retinol levels in man may lead to a reduction in cancer risk.