Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
D. Forman,D. G. Newell,F. Fullerton,J. W. G. Y. Yarnell,A. R. Stacey,Nicholas J. Wald,Freddy Sitas +6 more
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TLDR
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.Abstract:
OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.read more
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Helicobacter pylori infection and cancer.
TL;DR: The critical issue of whether H. pylori eradication may play a part in a strategy for the prevention of gastric cancer will be discussed.
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Interaction of MUC1 with beta-catenin modulates the Wnt target gene cyclinD1 in H. pylori-induced gastric cancer.
TL;DR: The findings indicate that MUC1 CT plays a role in the intracellular signaling through its interaction with β‐catenin and upregulate the Wnt target gene cyclinD1 in CagA H. pylori‐infected gastric carcinoma.
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Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms and gastric cancer risk: a prospective study of men in Shanghai, China
Kristin A. Moy,Jian-Min Yuan,Fung-Lung Chung,Xue-Li Wang,David Van Den Berg,Renwei Wang,Yu-Tang Gao,Mimi C. Yu +7 more
TL;DR: In this cohort of Chinese men at high risk for gastric cancer, isothiocyanates may protect against the development of gastric cancers, and the protection may be stronger for individuals genetically deficient in enzymes that metabolize these chemopreventive compounds.
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Effects of Helicobacter Pylori Eradication for Metachronous Gastric Cancer Prevention: A Randomized Controlled Trial
Ji Min Choi,Sang Gyun Kim,Jeongmin Choi,Jae Yong Park,Sooyeon Oh,Hyo Joon Yang,Joo Hyun Lim,Jong Pil Im,Joo Sung Kim,Hyun Chae Jung +9 more
TL;DR: H pylori eradication significantly reduces the incidence of MGC after ER of gastric tumors and should be considered for H pylory-positive gastric tumor patients treated with ER, according to a prospective, randomized controlled trial conducted in Seoul, Korea.
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Cancer in Rwanda.
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TL;DR: Chronic infection, including infection with HIV, high parity and multiple sexual partners are important determinants of cancer incidence in this population, and cancers known to be associated with HIV infection are relatively frequent.
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TL;DR: In this article, the prevalence of IgG antibodies to H. pylori in plasma samples taken in 1983 from 1882 men, aged 35-64 years, in 46 rural counties of the People's Republic of China.
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Low serum-vitamin-A and subsequent risk of cancer. Preliminary results of a prospective study.
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