Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
D. Forman,D. G. Newell,F. Fullerton,J. W. G. Y. Yarnell,A. R. Stacey,Nicholas J. Wald,Freddy Sitas +6 more
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TLDR
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.Abstract:
OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.read more
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Clarithromycin-resistant helicobacter pylori in patients with duodenal ulcer in the united states
TL;DR: Failed therapy with clarithromycin-based regimens is a growing cause of antimicrobial resistance in H. pylori in the United States and the increase in secondary resistance over a short period of time is worrisome.
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Relationship of Helicobacterpylori CagA Status to Gastric Cell Proliferation and Apoptosis
Theodore Rokkas,Spiros D. Ladas,Christos Liatsos,Evangelia Petridou,George Papatheodorou,Stamatis Theocharis,Andreas Karameris,Sotirios A. Raptis +7 more
TL;DR: It is concluded that H. pylori CagA(+) strains induce increased gastric cell proliferation, which is not accompanied by a parallel increase in apoptosis, which might explain the increased risk of forgastric carcinoma that is associated with infection by H.pylori cagA (+) strains.
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Helicobacter pylori infection, serum pepsinogen level and gastric cancer: a case-control study in Japan.
Haruhiko Fukuda,Daizo Saito,Shuya Hayashi,Hiroyuki Hisai,Hiroyuki Ono,Shigeaki Yoshida,Yanao Oguro,Takeshi Noda,Toshiya Sato,Masaru Katoh,Masaaki Terada,Takashi Sugimura +11 more
TL;DR: The risk of cancer associated with HP infection may be underestimated in studies with cross‐sectional exposure because of spontaneous disappearance of HP due to extended mucosal atrophy.
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Alcohol and Tobacco Use in Relation to Gastric Cancer: A Prospective Study of Men in Shanghai, China
TL;DR: It is suggested that cigarette smoking and alcohol consumption may exert independent effects on the development of gastric cancer in this high-risk population of men in Shanghai, China.
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Rising incidence of oesophageal adenocarcinoma in men in Australia
Reginald V. Lord,Matthew Law,Robyn L. Ward,Graham G. Giles,Robert J. Thomas,Vicky Thursfield +5 more
TL;DR: The incidence of cancer of the stomach not arising at the gastric cardia was significantly decreasing in men in all states and was also decreasing in women in allStates, although in women this decrease was statistically significant only in New South Wales, Victoria and Western Australia.
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Geographic association of Helicobacter pylori antibody prevalence and gastric cancer mortality in rural China.
D. Forman,Freddy Sitas,D. G. Newell,A. R. Stacey,J Boreham,Richard Peto,T. C. Campbell,J. Li,Junshi Chen +8 more
TL;DR: In this article, the prevalence of IgG antibodies to H. pylori in plasma samples taken in 1983 from 1882 men, aged 35-64 years, in 46 rural counties of the People's Republic of China.
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Low serum-vitamin-A and subsequent risk of cancer. Preliminary results of a prospective study.
TL;DR: Results suggest that measures taken to increase serum-retinol levels in man may lead to a reduction in cancer risk.