Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
D. Forman,D. G. Newell,F. Fullerton,J. W. G. Y. Yarnell,A. R. Stacey,Nicholas J. Wald,Freddy Sitas +6 more
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TLDR
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.Abstract:
OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.read more
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Characteristics of a Clinical Isolate of Urease-Negative Helicobacter pylori and its Ability to Induce Gastric Ulcers in Mongolian Gerbils
TL;DR: Investigation of the ability of the urease‐negative strain to colonize and subsequently damage the gastric mucosa in Mongolian gerbils found it to have the same virulence factors as Helicobacter pylori.
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Clinical relevance of Helicobacter pylori sabA genotype in Japanese clinical isolates
Ayako Yanai,Shin Maeda,Yoko Hikiba,Wataru Shibata,Tomoya Ohmae,Yoshihiro Hirata,Keiji Ogura,Haruhiko Yoshida,Masao Omata +8 more
TL;DR: This study assessed the relationship between the status of H.’pylori sialic acid‐binding adhesin (sabA) and the severity of gastric inflammation and diseases and found that the latter is strongly affected by the bacterial genotype.
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Efficacy of omeprazole and amoxicillin with either clarithromycin or metronidazole on eradication of Helicobacter pylori in Chinese peptic ulcer patients.
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TL;DR: One-week triple therapy with omeprazole and amoxicillin in combination with either clarithromycin or metronidazole is effective for the eradication of H. pylori and ulcer healing in Chinese peptic ulcer patients.
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Helicobacter pylori infection and gastric carcinoma in animal models.
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Geographic association of Helicobacter pylori antibody prevalence and gastric cancer mortality in rural China.
D. Forman,Freddy Sitas,D. G. Newell,A. R. Stacey,J Boreham,Richard Peto,T. C. Campbell,J. Li,Junshi Chen +8 more
TL;DR: In this article, the prevalence of IgG antibodies to H. pylori in plasma samples taken in 1983 from 1882 men, aged 35-64 years, in 46 rural counties of the People's Republic of China.
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Low serum-vitamin-A and subsequent risk of cancer. Preliminary results of a prospective study.
TL;DR: Results suggest that measures taken to increase serum-retinol levels in man may lead to a reduction in cancer risk.