Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
D. Forman,D. G. Newell,F. Fullerton,J. W. G. Y. Yarnell,A. R. Stacey,Nicholas J. Wald,Freddy Sitas +6 more
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TLDR
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.Abstract:
OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.read more
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Anti-unlcer and antimicrobial activities of sodium selenite against Helicobacter pylori: in vitro and in vivo evaluation.
B. Santhosh Kumar,Santosh K. Tiwari,G. Manoj,Amit Kunwar,Amrita N,G. Sivaram,Zakia Abid,Adeel Ahmad,Aleem Ahmed Khan,K. Indira Priyadarsini +9 more
TL;DR: Sodium selenite shows both ulcer healing and anti-H.
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Actividad antibacteriana de la Sangre de Grado (Croton lechleri) frente al Helicobacter pylori.
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TL;DR: The results suggest that the healing activity of “Sangre de grado” tested in previous studies and complemented with the antibacterial activity determined in the present study, would be the responsible for the curative capacity of this product in gastric ulcers.
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Helicobacter pylori and Other Gastric Helicobacter Species
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Helicobacter pylori-induced chronic inflammation causes telomere shortening of gastric mucosa by promoting PARP-1-mediated non-homologous end joining of DNA.
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TL;DR: DNA end joining assay showed that H. pylori-infected gastric mucosa had increased alternative NHEJ (non-homologous end joining), implicating that telomere shortening was caused by inflammation-mediated overproduction of reactive oxygen species and PARP-1, leading to telomeres shortening.
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Educational inequalities in mortality and associated risk factors: German- versus French-speaking Switzerland
David Faeh,Matthias Bopp +1 more
TL;DR: Characteristic differences in mortality and associated risk factors were found between German- and French-speaking Switzerland, some of which followed gradients described in Europe.
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Geographic association of Helicobacter pylori antibody prevalence and gastric cancer mortality in rural China.
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TL;DR: In this article, the prevalence of IgG antibodies to H. pylori in plasma samples taken in 1983 from 1882 men, aged 35-64 years, in 46 rural counties of the People's Republic of China.
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