Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
D. Forman,D. G. Newell,F. Fullerton,J. W. G. Y. Yarnell,A. R. Stacey,Nicholas J. Wald,Freddy Sitas +6 more
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TLDR
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.Abstract:
OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.read more
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Comparison of Helicobacter pylori Infection between Fukuoka, Japan and Chinju, Korea
Hee-Shang Youn,Seung-Chul Baik,Yun-Kyeong Cho,Hyang Ok Woo,Yoon‐Ok Ahn,Kyuchan Kim,Myung-Je Cho,Woo-Kon Lee,Gyung-Hyuck Ko,Kenji Okada,Kohji Ueda,Kwang-Ho Rhee +11 more
TL;DR: A seroepidemiological study is conducted to estimate the prevalence of H. pylori infection in Japan and Korea in order to explain the current change in the gastric cancer incidences between two countries.
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Helicobacter biology - discovery
Martin Buckley,Colm O'Morain +1 more
TL;DR: Improvements in diagnostic and therapeutic options, combined with the gradual acceptance of the aetiological role of an infective agent in peptic disease, have led to a remarkable change in the management of gastroduodenal conditions in the past decade.
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Helicobacter pylori test-and-treat' strategy for dyspeptic patients.
TL;DR: In this article, the authors present a test-and-treat strategy for dyspeptic patients with Helicobacter pylori infection in Swedish Journal of Gastroenterology.
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Cancer mortality and incidence in cement industry workers in Korea.
TL;DR: The result suggests a potential association between cement exposure and stomach cancer and suggests hexavalent chromium contained in cement might be a causative carcinogen.
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Association of Helicobacter pylori-related Distal Gastric Cancer with the HLA Class II Gene DQB1 * 0602 and cagA + Strains in a Southern European Population
Enrique Quintero,Ma. Angeles Pizarro,Luis Rodrigo,Josep M. Piqué,Angel Lanas,Julio Ponce,Gonzalo Miño,Javier P. Gisbert,Aurora Jurado,Ma. José Herrero,Alejandro Jiménez,Julio Torrado,Ana Ponte Md,Francisco Díaz‐de‐Rojas,Eduardo Salido +14 more
TL;DR: The influence of host HLA DQA1 and DQB1 loci, H. pylori genotype, and socio‐economic factors on predicting H.pylori‐associated distal gastric cancer in a southern European population is evaluated.
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TL;DR: In this article, the prevalence of IgG antibodies to H. pylori in plasma samples taken in 1983 from 1882 men, aged 35-64 years, in 46 rural counties of the People's Republic of China.
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