Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
D. Forman,D. G. Newell,F. Fullerton,J. W. G. Y. Yarnell,A. R. Stacey,Nicholas J. Wald,Freddy Sitas +6 more
Reads0
Chats0
TLDR
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.Abstract:
OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.read more
Citations
More filters
Journal ArticleDOI
Association between Helicobacter pylori and Serum Leptin in Iranian Dyspeptic Patients.
Gholamreza Hemmasi,Farhad Zamani,Mahmoodreza Khonsari,Masoudreza Sohrabi,Nafiseh Abdollahi,Hossein Ajdarkosh +5 more
TL;DR: Serum leptin level was measured before endoscopy, after overnight fasting, and a significant relationship between serum leptin level and gender was found and age was correlated with age.
Journal ArticleDOI
Efficacy of bismuth-based triple therapy in children with abdominal pain and Helicobacter pylori gastritis.
TL;DR: A 7-day course of bismuth-based triple therapy for H. pylori gastritis in children appears to be clinically as effective as a 14-day regimen, and the feasibility of a shorter therapeutic regimen may enhance patient compliance and provide a better chance of clinical benefit.
Journal ArticleDOI
Is there a role for helicobacter pylori infection in urological diseases
TL;DR: A simple hypothetical model relating H pylori infection to prostate and bladder diseases is proposed to stimulate the collaborative work between the urologists and scientists to explore this field which is underinvestigated to date.
Journal ArticleDOI
Differences in molecular alterations of hepatocellular carcinoma between patients with a sustained virological response and those with hepatitis C virus infection
Takehiro Hayashi,Akihiro Tamori,Manabu Nishikawa,Hiroyasu Morikawa,Masaru Enomoto,Hiroki Sakaguchi,Daiki Habu,Norifumi Kawada,Shoji Kubo,Shuhei Nishiguchi,Susumu Shiomi +10 more
TL;DR: This work compared molecular alterations in hepatocellular carcinoma (HCC) between patients with a sustained virological response (SVR) to IFN and patients with HCV.
Book ChapterDOI
Malignant Helicobacter pylori-Associated Diseases: Gastric Cancer and MALT Lymphoma.
TL;DR: A variation in a single amino-acid residue determines the magnitude for the pathogenic/oncogenic action of CagA, which may influence the worldwide landscape in the incidence of H. pylori-associated malignancies, especially gastric cancer.
References
More filters
Journal Article
Statistical methods in cancer research. Volume I - The analysis of case-control studies.
N. E. Breslow,N. E. Day +1 more
Statistical methods in cancer research. Vol. 1. The analysis of case-control studies.
N. E. Breslow,N. E. Day +1 more
TL;DR: Case-control studies have come into increasing favour, and they are now one of the commonest forms of epidemiol-ogical studies.
Journal ArticleDOI
The decline in gastric cancer: epidemiology of an unplanned triumph
Journal ArticleDOI
Geographic association of Helicobacter pylori antibody prevalence and gastric cancer mortality in rural China.
D. Forman,Freddy Sitas,D. G. Newell,A. R. Stacey,J Boreham,Richard Peto,T. C. Campbell,J. Li,Junshi Chen +8 more
TL;DR: In this article, the prevalence of IgG antibodies to H. pylori in plasma samples taken in 1983 from 1882 men, aged 35-64 years, in 46 rural counties of the People's Republic of China.
Journal ArticleDOI
Low serum-vitamin-A and subsequent risk of cancer. Preliminary results of a prospective study.
TL;DR: Results suggest that measures taken to increase serum-retinol levels in man may lead to a reduction in cancer risk.