Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
D. Forman,D. G. Newell,F. Fullerton,J. W. G. Y. Yarnell,A. R. Stacey,Nicholas J. Wald,Freddy Sitas +6 more
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TLDR
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.Abstract:
OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.read more
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Opposing Risks of Gastric Cardia and Noncardia Gastric Adenocarcinomas Associated With Helicobacter pylori Seropositivity
Farin Kamangar,Sanford M. Dawsey,Martin J. Blaser,Guillermo I. Perez-Perez,Pirjo Pietinen,Craig J. Newschaffer,Christian C. Abnet,Demetrius Albanes,Jarmo Virtamo,Philip R. Taylor +9 more
TL;DR: The hypothesis that decreasing H. pylori prevalence during the past century may have contributed to lower rates of noncardia cancer and higher rates of cardia cancer in Western countries is bolstered.
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Molecular mimicry of host structures by bacterial lipopolysaccharides and its contribution to disease
TL;DR: The core oligosaccharides of low-molecular-weight lipopolysaccharide (LPS) of pathogenic Neisseria spp.
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Iron acquisition and virulence in Helicobacter pylori: a major role for FeoB, a high-affinity ferrous iron transporter.
Jyoti Velayudhan,Nicky J. Hughes,Andrew A. McColm,Julie A. Bagshaw,Chris L. Clayton,Simon C. Andrews,David J. Kelly +6 more
TL;DR: The results are consistent with FeoB‐mediated Fe2+ uptake being a major pathway for H. pylori Fe acquisition in the low‐pH, low‐O2 environment of the stomach.
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Induction of Gastric Epithelial Cell Apoptosis by Helicobacter pylori Vacuolating Cytotoxin
TL;DR: Results indicate that VacA induces gastric epithelial cell apoptosis and suggest that differences in levels of gastric mucosal epithelial apoptosis among H. pylori-infected persons may result from strain-dependent variations in VacA structure.
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Virulence factors of Helicobacter pylori responsible for gastric diseases in Mongolian gerbil.
Keiji Ogura,Shin Maeda,Masafumi Nakao,Takeshi Watanabe,Mayumi Tada,Toshimasa Kyutoku,Haruhiko Yoshida,Yasushi Shiratori,Masao Omata +8 more
TL;DR: In this paper, the role of two genes, vacA and cagE, in the gastric pathogenesis induced by H. pylori using a long-term (62 wk) animal model was examined.
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