Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
D. Forman,D. G. Newell,F. Fullerton,J. W. G. Y. Yarnell,A. R. Stacey,Nicholas J. Wald,Freddy Sitas +6 more
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TLDR
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.Abstract:
OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.read more
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Association between Helicobacter pylori status and metachronous gastric cancer after endoscopic resection.
Sung Bum Kim,Si Hyung Lee,Seung Il Bae,Yo Han Jeong,Se Hoon Sohn,Kyeong Ok Kim,Byung Ik Jang,Tae Nyeun Kim +7 more
TL;DR: H. pylori status test seems to have no preventive effect on the development of metachronous gastric cancer after ESD for EGC.
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Transmission of infectious diseases through mouth-to-mouth ventilation: evidence-based or emotion-based medicine?
Seroprevalencia de la infección por Helicobacter pylori en pacientes con Gastritis Crónica, Úlcera Duodenal y Gástrica: Primer estudio de corte retrospectivo
Beatriz Gutiérrez,María Eugenia Cavazza,Diana Ortiz,María Correnti,Teresita Vidal,Francis Mégraud,Manuel Guerram,Patricia Álvarez +7 more
TL;DR: The aim was to determine the (Hp)-seroprevalence of the infection in a group of 300 consecutive adult subjects population submitted to upper digestive tract endoscopy clinics in three countries, Venezuela, Cuba and Republica Dominicana.
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Expression of bcl-2 in autoimmune and Helicobacter pylori-associated atrophic gastritis.
Y. Maor-Kendler,Gila Gabay,J. Bernheim,Timna Naftali,I. Lesin,G. Leichtman,I. Pomeranz,Novis B +7 more
TL;DR: These findings confirm that H. pylori-associatedatrophic gastritis and autoimmune atrophic Gastritis are two different conditions, but with equalexpression of bcl-2, which is a protooncogene, blocksapoptosis.
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Helicobacter pylori: past, present, and future.
TL;DR: Helicobacter pylori has been recognized as one of the most common chronic human infections and plays a key role in the aetiology of duodenal ulcer and may also be involved in the pathogenesis of gastric cancer.
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TL;DR: In this article, the prevalence of IgG antibodies to H. pylori in plasma samples taken in 1983 from 1882 men, aged 35-64 years, in 46 rural counties of the People's Republic of China.
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