Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
D. Forman,D. G. Newell,F. Fullerton,J. W. G. Y. Yarnell,A. R. Stacey,Nicholas J. Wald,Freddy Sitas +6 more
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TLDR
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.Abstract:
OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.read more
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High‐risk Population for Gastric Cancer Development Based on Serum Pepsinogen Status and Lifestyle Factors
Yutaka Yamaji,Hirotsugu Watabe,Haruhiko Yoshida,Takao Kawabe,Ryoichi Wada,Toru Mitsushima,Masao Omata +6 more
TL;DR: Serum pepsinogen status could identify people at high‐risk for gastric cancer development during a previous cohort study, but lifestyle‐related factors may additionally affect this risk.
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Bactericidal effect of a whey protein concentrate with anti-Helicobacter pylori activity.
TL;DR: To investigate the effect of whey protein concentrate enriched in anti‐Helicobacter pylori antibodies on growth of the organism in vitro.
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A novel Helicobacter pylori cell-surface polysaccharide.
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TL;DR: The findings revealed the bio-molecular basis for the observed serospecificity of H. pylori serotype O2, and that this unique bacterial PS must be included in the formulation of a multivalent LPS H.pylori vaccine.
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Quantitative analysis of representative proteome components and clustering of Helicobacter pylori clinical strains.
Jeong-Won Park,Jae-Young Song,Seung-Gyu Lee,Jin-Su Jun,Jeong-Uck Park,Mi-Ja Chung,Jung-Soo Ju,Damir Nizamutdinov,Myung-Woong Chang,Hee-Shang Youn,Hyung-Lyun Kang,Seung-Chul Baik,Woo-Kon Lee,Myung-Je Cho,Kwang-Ho Rhee +14 more
TL;DR: Representative proteome components of 71 clinical isolates of H. pylori were analyzed quantitatively to determine whether the protein expression levels were associated with gastric diseases and to cluster clinical isolate.
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Helicobacter pylori and Gastric Cancer: An Overrated Risk?
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