Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
D. Forman,D. G. Newell,F. Fullerton,J. W. G. Y. Yarnell,A. R. Stacey,Nicholas J. Wald,Freddy Sitas +6 more
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TLDR
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.Abstract:
OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.read more
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Differential expression of apoptosis receptors on diffuse and intestinal type stomach carcinoma.
H. Peter Vollmers,J. Dämmrich,Frank Hensel,Hanno Ribbert,Almut Meyer‐Bahlburg,Tobias Ufken‐Gaul,Marlene v. Korff,Hans Konrad Müller-Hermelink +7 more
TL;DR: Differences in the expression of specific apoptosis receptors and intracellular‐related signals might help to explain the molecular pathogenesis of these two types of stomach adenocarcinoma.
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Detection of Helicobacter pylori specific DNA in human atheromatous coronary arteries and its association to prior myocardial infarction and unstable angina
M. Kowalski,W. Rees,P C Konturek,R. Grove,T. Scheffold,Holger Meixner,M. Brunec,N. Franz,J.W. Konturek,Piotr Pieniazek,Eckhart G. Hahn,Stanislaw J. Konturek,J. Thale,H. Warnecke +13 more
TL;DR: Identification of DNA in atherosclerotic plaques of patients with severe coronary artery disease supports the hypothesis that Helicobacter pylori infection may influence the development of atherosclerosis.
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A Review of the Postulated Mechanisms Concerning the Association of Helicobacter pylori with Ischemic Heart Disease
TL;DR: H. pylori infection and ischemic heart disease has been suggested by a series of studies focusing on epidemiologic evidence, dyslipidemic alterations, upregulation of inflammatory markers or homocysteine levels, induction of hypercoagulability, oxidation of low‐density lipoprotein, causation of impaired endothelial function and participation of certain antigens and antibodies in a cross‐reactivity model.
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Prospective study of educational background and stomach cancer in Japan.
Yoshihisa Fujino,Akiko Tamakoshi,Yoshiyuki Ohno,Tetsuya Mizoue,Noritaka Tokui,Takesumi Yoshimura +5 more
TL;DR: The expected inverse correlation between education level and death from stomach cancer was observed in men, but this association could not be explained by differences in dietary habits, smoking, or alcohol consumption associated with socioeconomic status.
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Helicobacter pylori, pepsinogen, and risk for gastric adenocarcinoma.
Julie Parsonnet,I M Samloff,Lorene M. Nelson,Norman Orentreich,Joseph H. Vogelman,Gary D. Friedman +5 more
TL;DR: The objective of this project was to determine the association of Helicobacter pylori infection and serum pepsinogen levels on subsequent risk for gastric adenocarcinoma and there was interaction between the two variables.
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TL;DR: In this article, the prevalence of IgG antibodies to H. pylori in plasma samples taken in 1983 from 1882 men, aged 35-64 years, in 46 rural counties of the People's Republic of China.
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