Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
D. Forman,D. G. Newell,F. Fullerton,J. W. G. Y. Yarnell,A. R. Stacey,Nicholas J. Wald,Freddy Sitas +6 more
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TLDR
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.Abstract:
OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.read more
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Atrophic gastritis and intestinal metaplasia in Helicobacter pylori infection: The role of caga status
Michele Sozzi,M. Valentini,Natale Figura,P. De Paoli,R. Tedeschi,Annunziata Gloghini,Diego Serraino,M. Poletti,A. Carbone +8 more
TL;DR: The results seem to suggest that the CagA status could be a helpful parameter to define a subgroup of H. pylori-infected patients at increased risk of developing gastric adenocarcinoma, in addition to higher degrees of gastritis.
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Prevalence of Helicobacter pylori infection in subtypes of gastric cancer
TL;DR: The association with H. pylori infection is similar regardless of the histological features of the tumor, whereas it is stronger for noncardiac gastric cancer than for cardiac cancer.
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CagA seropositivity associated with development of gastric cancer in a Japanese population.
TL;DR: Investigating whether CagA seropositivity is associated with increasing risk of gastric cancer in a Japanese population that has a much higher incidence of Gastric cancer than western populations suggests that Cag a seropositive isassociated with increased risk of gastroenterological cancer in Japanese populations.
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Cancer incidence and mortality in Portugal
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D. Forman,Freddy Sitas,D. G. Newell,A. R. Stacey,J Boreham,Richard Peto,T. C. Campbell,J. Li,Junshi Chen +8 more
TL;DR: In this article, the prevalence of IgG antibodies to H. pylori in plasma samples taken in 1983 from 1882 men, aged 35-64 years, in 46 rural counties of the People's Republic of China.
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