Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
D. Forman,D. G. Newell,F. Fullerton,J. W. G. Y. Yarnell,A. R. Stacey,Nicholas J. Wald,Freddy Sitas +6 more
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TLDR
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.Abstract:
OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.read more
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Reducing population salt intake worldwide: from evidence to implementation.
Feng J. He,Graham A. MacGregor +1 more
TL;DR: A modest reduction in population salt intake worldwide will result in a major improvement in public health, and is probably a major cause of stomach cancer.
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An Inverse Relation between cagA + Strains of Helicobacter pylori Infection and Risk of Esophageal and Gastric Cardia Adenocarcinoma
Wong Ho Chow,Martin J. Blaser,Martin J. Blaser,William J. Blot,Marilie D. Gammon,Thomas L. Vaughan,Thomas L. Vaughan,Harvey A. Risch,Guillermo I. Perez-Perez,Janet B. Schoenberg,Janet L. Stanford,Janet L. Stanford,Heidi Rotterdam,A. Brian West,A. Brian West,Joseph F. Fraumeni +15 more
TL;DR: The findings suggest that the effects of H. pylori strains on tumor development vary by anatomical site, and may be associated with the rising incidence of esophageal/gastric cardia adenocarcinomas in industrialized countries.
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Helicobacter infection and gastric neoplasia
Richard M. Peek,Jean E. Crabtree +1 more
TL;DR: Insight is gained into the pathogenesis of H. pylori‐induced gastritis and adenocarcinoma, not only to develop more effective treatments for gastric cancer, but also because it might serve as a paradigm for the role of chronic inflammation in the genesis of other malignancies that arise within the gastrointestinal tract.
Journal ArticleDOI
Progression of chronic atrophic gastritis associated with Helicobacter pylori infection increases risk of gastric cancer
Hiroshi Ohata,Shintaro Kitauchi,Noriko Yoshimura,Kouichi Mugitani,Masataka Iwane,Hideya Nakamura,Akiyoshi Yoshikawa,Kimihiko Yanaoka,Kenji Arii,Hideyuki Tamai,Yasuhito Shimizu,Tatsuya Takeshita,Osamu Mohara,Masao Ichinose +13 more
TL;DR: It is compelling evidence that severe gastritis with extensive intestinal metaplasia is a major risk factor for gastric cancer, and they confirm the previously described model of stomach carcinogenesis: the gastritis‐metaplasia‐carcinoma sequence.
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TL;DR: In this article, the prevalence of IgG antibodies to H. pylori in plasma samples taken in 1983 from 1882 men, aged 35-64 years, in 46 rural counties of the People's Republic of China.
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Low serum-vitamin-A and subsequent risk of cancer. Preliminary results of a prospective study.
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