Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
D. Forman,D. G. Newell,F. Fullerton,J. W. G. Y. Yarnell,A. R. Stacey,Nicholas J. Wald,Freddy Sitas +6 more
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TLDR
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.Abstract:
OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.read more
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The Association Between Helicobacter pylori Infection and Early Gastric Cancer: A Meta-Analysis
TL;DR: This study indicates that H. pylori infection is strongly associated with early gastric cancer when compared with non-neoplasm controls or advanced Gastric cancer.
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Systematic review: Helicobacter pylori eradication for the prevention of gastric cancer.
TL;DR: Helicobacter pylori is recognized as one of the most significant risk factors for gastric cancer, and H. pylora eradication has been proposed as a possible primary chemo‐preventive strategy to reduce Gastric cancer incidence.
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Helicobacter pylori and gastric cancer.
TL;DR: The International Agency of Research on Cancer has categorized Helicobacter pylori infection as a class I carcinogen and a definite cause of human gastric cancer and several aspects of gastric epithelial cell function that may be related to cancer.
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Functional Analysis of the cag Pathogenicity Island in Helicobacter pylori Isolates from Patients with Gastritis, Peptic Ulcer, and Gastric Cancer
Steffen Backert,Tobias Schwarz,Stephan Miehlke,Christian Kirsch,Christian Sommer,Terry Kwok,Markus Gerhard,Ulf B. Goebel,Norbert Lehn,Wolfgang Koenig,Thomas F. Meyer +10 more
TL;DR: CagA proteins with unique features, CagA subspecies of various sizes, and new functional properties for the phenotypic outcomes are revealed and it is shown that induction of AGS cell motility and elongation are two independent processes.
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Salty Food Intake and Risk of Helicobacter pylori Infection
TL;DR: Consumption of salty foods appears to increase the risk of H. pylori infection, which could be a marker of salty food intake or an intermediate risk factor in the etiologic sequence between salty food consumption and gastric cancer.
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D. Forman,Freddy Sitas,D. G. Newell,A. R. Stacey,J Boreham,Richard Peto,T. C. Campbell,J. Li,Junshi Chen +8 more
TL;DR: In this article, the prevalence of IgG antibodies to H. pylori in plasma samples taken in 1983 from 1882 men, aged 35-64 years, in 46 rural counties of the People's Republic of China.
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Low serum-vitamin-A and subsequent risk of cancer. Preliminary results of a prospective study.
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