Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
D. Forman,D. G. Newell,F. Fullerton,J. W. G. Y. Yarnell,A. R. Stacey,Nicholas J. Wald,Freddy Sitas +6 more
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TLDR
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.Abstract:
OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.read more
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Helicobacter pylori antibodies and gastric cancer in Iceland - The decline in IgG antibody level is a risk factor.
Hrafn Tulinius,Helga M. Ögmundsdóttir,Karl G. Kristinsson,Helgi Sigvaldason,E. Sigvaldadottir,G. Kristjansdottir,N. Sigfusson +6 more
TL;DR: It is concluded that this decline in antibody levels in cases, and not in controls, supports an active role of H. pylori in the pathogenesis of gastric cancer by causing atrophic gastritis, and provides a better risk assessment for Gastric cancer compared to single measurements.
Journal ArticleDOI
Human papilloma virus in retinoblastoma tissues from Korean patients.
TL;DR: This study, being the first study in the Korean population, proposes that HPV infection may have no causal relationship with retinoblastoma in Koreans.
Journal ArticleDOI
Histological evaluation of patients with gastritis at high risk of developing gastric cancer using a conventional index.
Aki Tanaka,Tomoari Kamada,Kazuhiko Inoue,Akiko Shiotani,Hiroaki Kusunoki,Noriaki Manabe,Masanori Ito,Jiro Hata,Ken Haruma +8 more
TL;DR: H. pylori-positive subjects at high risk of developing GCa by assessment of the histopathological findings in the non-cancer-containing mucosa of patients with and without GCa are identified by means of a modified Meining's gastric cancer risk index.
Journal ArticleDOI
Biochemical Markers of Bone Metabolism in Children with Helicobacter pylori Infection
TL;DR: Serum levels of intact parathyroid hormone, ß-collagen I carboxy terminal telopeptide, total alkaline phosphatase (ALP), bone-specific ALP, and N-terminal cross-links of human procollagen type I, N-mid-osteocalcin, calcium, phosphate, ferritin, and estradiol did not differ significantly between H. pylori(+) and H.
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Serological Immunoglobulin G antibody titers to Helicobacter pylori in Japanese Brazilian and Non-Japanese Brazilian gastric cancer patients and controls in São Paulo.
Naoko Fujioka,Michael T. Fahey,Gerson Shigeaki Hamada,Inês Nobuko Nishimoto,Luiz Paulo Kowalski,Kiyoshi Iriya,Joaquim José Gama Rodrigues,Hisao Tajiri,Shoichiro Tsugane +8 more
TL;DR: A cross-sectional comparison of antibody titers to H. pylori in Japanese Brazilian, and non-Japanese Brazilian GC patients and their controls shows that a high titer was associated with less likelihood of GC for both ethnic groups, and a low titer is regarded as a sign of the necessity of close screening for GC in bothethnic groups.
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