Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
D. Forman,D. G. Newell,F. Fullerton,J. W. G. Y. Yarnell,A. R. Stacey,Nicholas J. Wald,Freddy Sitas +6 more
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TLDR
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.Abstract:
OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.read more
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Presence of Helicobacter pylori in supragingival dental plaque of individuals with periodontal disease and upper gastric diseases.
Denise Gomes da Silva,Roy H. Stevens,Jacyara Maria Brito Macedo,Rodolpho Mattos Albano,Márcio Eduardo Vieira Falabella,Ricardo Guimarães Fischer,Enno C. I. Veerman,Eduardo Muniz Barretto Tinoco +7 more
TL;DR: There was an association between the supragingival colonization of H. pylori and oral hygiene parameters such as the presence of plaque and gingival bleeding in individuals with periodontal disease and upper gastric diseases.
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Role of Helicobacter pylori in Gastric Carcinogenesis: The Origin of Gastric Cancers and Heterotopic Proliferative Glands in Mongolian Gerbils
TL;DR: H. pylori is not an initiator, but rather a strong promoter of gastric carcinogenesis, whose eradication, together with reduction in salt intake, might effectively prevent gastric cancer development.
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Socioeconomic status and stomach cancer incidence in men: Results from the Netherlands Cohort Study
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The evaluation of putative virulence factors of Helicobacter pylori for gastroduodenal disease by use of a short-term Mongolian gerbil infection model
Masao Akanuma,Shin Maeda,Keiji Ogura,Yuzo Mitsuno,Yoshihiro Hirata,Tsuneo Ikenoue,Motoyuki Otsuka,Takeshi Watanabe,Yutaka Yamaji,Haruhiko Yoshida,Takao Kawabe,Yasushi Shiratori,Masao Omata +12 more
TL;DR: The Mongolian gerbil model was useful for the screening of virulence determinants in vivo, which confirmed the importance of cag PAI while questioning that of HP0499.
References
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Journal Article
Statistical methods in cancer research. Volume I - The analysis of case-control studies.
N. E. Breslow,N. E. Day +1 more
Statistical methods in cancer research. Vol. 1. The analysis of case-control studies.
N. E. Breslow,N. E. Day +1 more
TL;DR: Case-control studies have come into increasing favour, and they are now one of the commonest forms of epidemiol-ogical studies.
Journal ArticleDOI
The decline in gastric cancer: epidemiology of an unplanned triumph
Journal ArticleDOI
Geographic association of Helicobacter pylori antibody prevalence and gastric cancer mortality in rural China.
D. Forman,Freddy Sitas,D. G. Newell,A. R. Stacey,J Boreham,Richard Peto,T. C. Campbell,J. Li,Junshi Chen +8 more
TL;DR: In this article, the prevalence of IgG antibodies to H. pylori in plasma samples taken in 1983 from 1882 men, aged 35-64 years, in 46 rural counties of the People's Republic of China.
Journal ArticleDOI
Low serum-vitamin-A and subsequent risk of cancer. Preliminary results of a prospective study.
TL;DR: Results suggest that measures taken to increase serum-retinol levels in man may lead to a reduction in cancer risk.