Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
D. Forman,D. G. Newell,F. Fullerton,J. W. G. Y. Yarnell,A. R. Stacey,Nicholas J. Wald,Freddy Sitas +6 more
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TLDR
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.Abstract:
OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.read more
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Sero-prevalence and associated factors of Helicobacter pylori infection among adult patients with dyspepsia attending the gastroenterology unit in a tertiary hospital in Mwanza, Tanzania
Hyasinta Jaka,Martha F. Mushi,Mariam M. Mirambo,Leonard Wilson,Jeremiah Seni,Majigo Mtebe,Stephen E. Mshana +6 more
TL;DR: The seroprevalence of H.pylori among dyspeptic patients is high in this setting and the community in Mwanza should be educated on the use of safe drinking water in order to minimize H. pylori infections.
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Detection of serum IgG antibody againstHelicobacter pylori from childhood in a Japanese population
Norio Matsukura,Masahiko Onda,Akira Tokunaga,Tadashi Teramoto,Itsuo Fujita,Takeshi Okuda,Kiyohiko Yamashita +6 more
TL;DR: Seropositivity was seen in 41% of individuals aged less than 1 year, and in 9% of those aged 1–2 years, indicating the possibility that IgG antibody in infancy is derived from the mother, and the spread ofH.
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Gastric Pouch Adenocarcinoma and Tubular Adenoma of the Pylorus: A Field Effect of Dysplasia following Bariatric Surgery
TL;DR: The present example of neoplastic change in both the pouch and pylorus may indicate that a field effect for dysplasia develops subsequent to vertical banded gastroplasty (VBG), and the pathogenesis of gastric pouch carcinoma is discussed.
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Role of proteinase-activated receptor-2 on cyclooxygenase-2 expression in H. pylori - Infected gastric epithelial cells
TL;DR: It is found that H. pylori induces COX‐2 expression, which is mediated by both activation and expression of PAR‐2 in gastric epithelial cells, which may lead to mutagenesis and subsequent metaplasia, dysPlasia, and cancer formation.
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Bactericidal and Morphological Effects of NE-2001, a Novel Synthetic Agent Directed against Helicobacter pylori
TL;DR: The results suggest that NE-2001 may have the potential to be developed as a candidate agent for the treatment of Helicobacter pylori infection.
References
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Journal Article
Statistical methods in cancer research. Volume I - The analysis of case-control studies.
N. E. Breslow,N. E. Day +1 more
Statistical methods in cancer research. Vol. 1. The analysis of case-control studies.
N. E. Breslow,N. E. Day +1 more
TL;DR: Case-control studies have come into increasing favour, and they are now one of the commonest forms of epidemiol-ogical studies.
Journal ArticleDOI
The decline in gastric cancer: epidemiology of an unplanned triumph
Journal ArticleDOI
Geographic association of Helicobacter pylori antibody prevalence and gastric cancer mortality in rural China.
D. Forman,Freddy Sitas,D. G. Newell,A. R. Stacey,J Boreham,Richard Peto,T. C. Campbell,J. Li,Junshi Chen +8 more
TL;DR: In this article, the prevalence of IgG antibodies to H. pylori in plasma samples taken in 1983 from 1882 men, aged 35-64 years, in 46 rural counties of the People's Republic of China.
Journal ArticleDOI
Low serum-vitamin-A and subsequent risk of cancer. Preliminary results of a prospective study.
TL;DR: Results suggest that measures taken to increase serum-retinol levels in man may lead to a reduction in cancer risk.