Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
D. Forman,D. G. Newell,F. Fullerton,J. W. G. Y. Yarnell,A. R. Stacey,Nicholas J. Wald,Freddy Sitas +6 more
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TLDR
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.Abstract:
OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.read more
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Helicobacter pylori infection. Implications for ulcer therapy in older patients.
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Infection with Helicobacter pylori Strains Possessing cagA Is Associated with an Increased Risk of Developing Adenocarcinoma of the Stomach
Martin J. Blaser,Guillermo I. Perez-Perez,Harry Kleanthous,Timothy L. Cover,Richard M. Peek,Po-Huang Chyou,Grant N. Stemmermann,Abraham M. Y. Nomura +7 more
TL;DR: It is concluded that infection with a cagA-positive H. pylori strain in comparison with acagA -negative strain somewhat increases the risk for development of gastric cancer, especially intestinal type affecting the distal stomach.
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Epidemiology of gastric cancer
TL;DR: Diverging trends in the incidence of gastric cancer by tumor location suggest that they may represent two diseases with different etiologies, and strategies for primary prevention are discussed.
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Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial.
Benjamin C.Y. Wong,Shiu Kum Lam,Wai Man Wong,Jian Shun Chen,Ting Ting Zheng,Rui E. Feng,Kam Chuen Lai,Wayne Hsing Cheng Hu,Siu Tsan Yuen,Suet Yi Leung,Daniel Y. T. Fong,Joanna Ho,Chi Kong Ching,Jun Shi Chen +13 more
TL;DR: It was found that the incidence of gastric cancer development at the population level was similar between participants receiving H pylori eradication treatment and those receiving placebo during a period of 7.5 years in a high-risk region of China.
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Epidemiology of gastric cancer.
Alfred I. Neugut,M Hayek,G Howe +2 more
TL;DR: The incidence of gastric cancer varies widely by country and population, with higher rates among the lower socioeconomic groups as discussed by the authors, although rates have generally decreased, there has been a dramatic increase in the incidence of Gastric cancer in the cardia.
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TL;DR: In this article, the prevalence of IgG antibodies to H. pylori in plasma samples taken in 1983 from 1882 men, aged 35-64 years, in 46 rural counties of the People's Republic of China.
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