Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
D. Forman,D. G. Newell,F. Fullerton,J. W. G. Y. Yarnell,A. R. Stacey,Nicholas J. Wald,Freddy Sitas +6 more
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TLDR
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.Abstract:
OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.read more
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Serum antibodies against Helicobacter pylori proteins VacA and CagA are associated with increased risk for gastric adenocarcinoma.
Jochen Rudi,Christof Kolb,Matthias Maiwald,Ivan Zuna,Axel von Herbay,Peter R. Galle,Wolfgang Stremmel +6 more
TL;DR: There is evidence that infection with VacA- or CagA-producing H. pylori strains increases the risk of developing gastric cancer, especially in younger patients.
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The morphological transition of Helicobacter pylori cells from spiral to coccoid is preceded by a substantial modification of the cell wall.
K Costa,Gerold Bacher,Günter Allmaier,Maria Gloria Dominguez-Bello,Lars Engstrand,Lars Engstrand,P Falk,P Falk,M A de Pedro,F García-del Portillo +9 more
TL;DR: The peptidoglycan (murein) of Helicobacter pylori has been investigated by high-performance liquid chromatography and mass spectrometric techniques and triggered an increase in N-acetylglucosaminyl-N-acetymuramyl-L-Ala-D-Glu (approximately 20 mol%), apparently at the expense of monomeric muropeptides with tri- and tetrapeptide side chains.
Journal ArticleDOI
Helicobacter pylori, dietary factors, and atrophic gastritis in five Japanese populations with different gastric cancer mortality
Shoichiro Tsugane,Michinori Kabuto,Hideki Imai,Fred Gey,Yuko Tei,Tomoyuki Hanaoka,Kokichi Sugano,Shaw Watanabe +7 more
TL;DR: H. pylori infection is associated with the formation of atrophic gastritis, while β-carotene protects its advancement as well as formation, and these factors did not explain the differences in atrophic Gastritis prevalence among the five regions.
Journal ArticleDOI
Helicobacter rodentium sp. nov., a urease-negative Helicobacter species isolated from laboratory mice.
Zeli Shen,James G. Fox,Floyd E. Dewhirst,Bruce J. Paster,C J Foltz,L L Yan,Brian D. Shames,L. Perry +7 more
TL;DR: A spiral-shaped bacterium with bipolar, single, nonsheathed flagella was isolated from the intestines of laboratory mice, which is the first urease-negative, murine Helicobacter spp.
Journal ArticleDOI
Helicobacter pylori infection, glandular atrophy and intestinal metaplasia in superficial gastritis, gastric erosion, erosive gastritis, gastric ulcer and early gastric cancer.
TL;DR: The grades of mucosa glandular atrophy and intestinal metaplasia were significantly highest in early gastric cancer, lower in gastric ulcer, the next were erosive gastritis, gastric erosion, the lowest in superficial gastritis (P<0.01); however, there was no significant difference compared with erosives gastritis.
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