Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
D. Forman,D. G. Newell,F. Fullerton,J. W. G. Y. Yarnell,A. R. Stacey,Nicholas J. Wald,Freddy Sitas +6 more
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TLDR
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.Abstract:
OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.read more
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Eradication of Helicobacter pylori: therapies and clinical implications.
TL;DR: It is premature to recommend large-scale eradication of H. pylori as a valid strategy for the primary prevention of gastric cancer but it is likely to emerge as the most rational and cost-effective treatment for duodenal ulcer.
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An Update on Helicobacter pylori as the Cause of Gastric Cancer.
TL;DR: H. pylori strain-specific components act in combination with host factors and environmental and dietary factors to greatly enhance the inflammatory response and thus the cancer risk, and population-wide eradication of H.pylori will result in gastric cancer becoming a vanishingly rare disease.
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High Dose Ilaprazole/Amoxicillin as First-Line Regimen for Helicobacter pylori Infection in Korea
TL;DR: A high dose of ilaprazole + amoxicillin was ineffective as the first-line therapy for eradicating H. pylori in Korea and future studies should focus on intragastric pH measurements and assess am toxicillin resistance.
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Recent Developments of Systemic Chemotherapy for Gastric Cancer.
TL;DR: A combination strategy simultaneously inhibiting several pathways and/or stricter patient selection for better response to targeted drugs are needed to improve clinical outcomes in this field.
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Genotyping of the cagA gene of Helicobacter pylori on immunohistochemistry with East Asian CagA-specific antibody.
Ryoko Kanada,Tomohisa Uchida,Yoshiyuki Tsukamoto,Lam Tung Nguyen,Naoki Hijiya,Keiko Matsuura,Masaaki Kodama,Tadayoshi Okimoto,Kazunari Murakami,Toshio Fujioka,Shigetaka Yanagisawa,Masatsugu Moriyama +11 more
TL;DR: Diagnosis of the cagA genotype of H.’pylori on immunohistochemistry using the α‐EAS Ab was highly sensitive and specific, suggesting that Immunohistochemical diagnosis of thecagA Genotype is useful for diagnosis ofThe cagB genotype.
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Geographic association of Helicobacter pylori antibody prevalence and gastric cancer mortality in rural China.
D. Forman,Freddy Sitas,D. G. Newell,A. R. Stacey,J Boreham,Richard Peto,T. C. Campbell,J. Li,Junshi Chen +8 more
TL;DR: In this article, the prevalence of IgG antibodies to H. pylori in plasma samples taken in 1983 from 1882 men, aged 35-64 years, in 46 rural counties of the People's Republic of China.
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Low serum-vitamin-A and subsequent risk of cancer. Preliminary results of a prospective study.
TL;DR: Results suggest that measures taken to increase serum-retinol levels in man may lead to a reduction in cancer risk.