Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
D. Forman,D. G. Newell,F. Fullerton,J. W. G. Y. Yarnell,A. R. Stacey,Nicholas J. Wald,Freddy Sitas +6 more
Reads0
Chats0
TLDR
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.Abstract:
OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.read more
Citations
More filters
Journal ArticleDOI
Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer
TL;DR: Study of the role of CagA during neoplastic transformation will provide an excellent opportunity to understand molecular processes underlying “Hit-and-Run” carcinogenesis.
Journal ArticleDOI
Genetic alterations in gastric cancer: Relation to histological subtypes, tumor stage, and Helicobacter pylori infection
Ming-Shiang Wu,Chia-Tung Shun,Hsiu-Po Wang,Jin-Chuan Sheu,Wei-Jei Lee,Teh-Hong Wang,Jaw-Town Lin +6 more
TL;DR: A distinct genetic pathway exists in gastric carcinogenesis of different histological subtypes and their tumor progression, in which H. pylori infection may play an equal role or no role.
Journal ArticleDOI
Screening of anti-Helicobacter pylori herbs deriving from Taiwanese folk medicinal plants
Yuan-Chuen Wang,Tung-Liang Huang +1 more
TL;DR: In this study, extracts from 50 Taiwanese folk medicinal plants were examined and screened for anti-Helicobacter pylori activity, and about half of the Taiwanese Folk medicinal plants tested, demonstrated to possess higher anti-H.
Journal ArticleDOI
Helicobacter antibodies in 1973 and 1994 in the adult population of Vammala, Finland.
Timo U. Kosunen,Arpo Aromaa,Paul Knekt,Anniina Salomaa,Hilpi Rautelin,P. Lohi,Olli P. Heinonen +6 more
TL;DR: The decrease in the seroprevalence rate in the population and the persistence of individual antibody status over two decades support a difference in H. pylori infection rates among birth cohorts over time rather than continuous acquisition of new infections with advancing age.
Journal ArticleDOI
Risk Factors for Hepatitis C Virus Seropositivity in Heterosexual Couples
Dennis Osmond,Nancy Padian,Haynes W. Sheppard,Sarah O. Glass,Stephen Shiboski,Arthur Reingold +5 more
TL;DR: The results provide little evidence of HCV sexual transmission but are consistent with infrequent sexual transmission and corroborate the importance of injection drug use and transfusion of blood or blood products in transmitting HCV and underscore the need for ascertaining parenteral exposures when examining sexual transmission ofHCV.
References
More filters
Journal Article
Statistical methods in cancer research. Volume I - The analysis of case-control studies.
N. E. Breslow,N. E. Day +1 more
Statistical methods in cancer research. Vol. 1. The analysis of case-control studies.
N. E. Breslow,N. E. Day +1 more
TL;DR: Case-control studies have come into increasing favour, and they are now one of the commonest forms of epidemiol-ogical studies.
Journal ArticleDOI
The decline in gastric cancer: epidemiology of an unplanned triumph
Journal ArticleDOI
Geographic association of Helicobacter pylori antibody prevalence and gastric cancer mortality in rural China.
D. Forman,Freddy Sitas,D. G. Newell,A. R. Stacey,J Boreham,Richard Peto,T. C. Campbell,J. Li,Junshi Chen +8 more
TL;DR: In this article, the prevalence of IgG antibodies to H. pylori in plasma samples taken in 1983 from 1882 men, aged 35-64 years, in 46 rural counties of the People's Republic of China.
Journal ArticleDOI
Low serum-vitamin-A and subsequent risk of cancer. Preliminary results of a prospective study.
TL;DR: Results suggest that measures taken to increase serum-retinol levels in man may lead to a reduction in cancer risk.