Journal ArticleDOI
Basilar artery occlusion
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TLDR
If BAO is recognised early and confirmed with multimodal CT or MRI, intravenous thrombolysis or endovascular treatment can be undertaken, however, the best treatment approach to improve clinical outcome still needs to be ascertained.Abstract:
The clinical presentation of basilar artery occlusion (BAO) ranges from mild transient symptoms to devastating strokes with high fatality and morbidity. Often, non-specific prodromal symptoms such as vertigo or headaches are indicative of BAO, and are followed by the hallmarks of BAO, including decreased consciousness, quadriparesis, pupillary and oculomotor abnormalities, dysarthria, and dysphagia. When clinical findings suggest an acute brainstem disorder, BAO has to be confirmed or ruled out as a matter of urgency. If BAO is recognised early and confirmed with multimodal CT or MRI, intravenous thrombolysis or endovascular treatment can be undertaken. The goal of thrombolysis is to restore blood flow in the occluded artery and salvage brain tissue; however, the best treatment approach to improve clinical outcome still needs to be ascertained.read more
Citations
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Journal ArticleDOI
Ischemic posterior circulation stroke: a review of anatomy, clinical presentations, diagnosis, and current management.
TL;DR: The anatomical, etiological, and clinical classification of PC strokes is discussed, diagnostic pitfalls are identified, and current therapeutic regimens are overviewed to identify diagnostic pitfalls.
Journal ArticleDOI
Posterior circulation ischaemic stroke.
Aine Merwick,David J. Werring +1 more
TL;DR: Preceding posterior circulation TIA or other transient brainstem symptoms, particularly if recurrent, signal a high risk of impending ischaemic stroke and should prompt specialist urgent referral for further management.
Journal ArticleDOI
Posterior circulation ischaemic stroke and transient ischaemic attack: diagnosis, investigation, and secondary prevention
TL;DR: Improved methods of non-invasive imaging of the vertebrobasilar arterial tree have been used in recent prospective follow-up studies, which have shown a high risk of early recurrent stroke, particularly when there is associated vertebro Basilar stenosis.
Journal ArticleDOI
Thrombolysis of basilar artery occlusion: Impact of baseline ischemia and time
Daniel Strbian,Tiina Sairanen,Heli Silvennoinen,Oili Salonen,Markku Kaste,Perttu J. Lindsberg +5 more
TL;DR: To evaluate the impact of extensive baseline ischemic changes on functional outcome after thrombolysis of basilar artery occlusion (BAO), and to study the effect of time to treatment in the absence of such findings.
Journal ArticleDOI
The Basilar Artery International Cooperation Study (BASICS): study protocol for a randomised controlled trial.
Erik J.R.J. van der Hoeven,Wouter J. Schonewille,Jan Albert Vos,Ale Algra,Heinrich J. Audebert,Eivind Berge,Alfonso Ciccone,Mikael Mazighi,Patrik Michel,Keith W. Muir,Victor Obach,Volker Puetz,C.A.C. Wijman,Andrea Zini,Jaap Kappelle +14 more
TL;DR: BASICS is a randomised controlled, multicentre, open label, phase III intervention trial with blinded outcome assessment, investigating the efficacy and safety of additional IAT after IVT in patients with BAO.
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Mechanical Thrombectomy for Acute Ischemic Stroke: Final Results of the Multi MERCI Trial
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TL;DR: Higher rates of recanalization were associated with a newer generation thrombectomy device compared with first-generation devices, but these differences did not achieve statistical significance.
Journal ArticleDOI
The penumbra pivotal stroke trial: safety and effectiveness of a new generation of mechanical devices for clot removal in intracranial large vessel occlusive disease.
TL;DR: The results suggest the Penumbra System allows safe and effective revascularization in patients experiencing ischemic stroke secondary to large vessel occlusive disease who present within 8 hours from symptom onset.
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