Open AccessDOI
Biomimetic peptide self-assembly for functional materials
Aviad Levin,Tuuli A. Hakala,Lee Schnaider,Gonçalo J. L. Bernardes,Gonçalo J. L. Bernardes,Ehud Gazit,Tuomas P. J. Knowles +6 more
- Vol. 4, Iss: 11, pp 615-634
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TLDR
This Review describes how synthetic peptides afford tunable scaffolds for biomineralization, drug delivery and tissue growth and discusses recent conceptual and experimental advances in self-assembling artificial peptidic materials.Abstract:
Natural biomolecular systems have evolved to form a rich variety of supramolecular materials and machinery fundamental to cellular function. The assembly of these structures commonly involves interactions between specific molecular building blocks, a strategy that can also be replicated in an artificial setting to prepare functional materials. The self-assembly of synthetic biomimetic peptides thus allows the exploration of chemical and sequence space beyond that used routinely by biology. In this Review, we discuss recent conceptual and experimental advances in self-assembling artificial peptidic materials. In particular, we explore how naturally occurring structures and phenomena have inspired the development of functional biomimetic materials that we can harness for potential interactions with biological systems. As our fundamental understanding of peptide self-assembly evolves, increasingly sophisticated materials and applications emerge and lead to the development of a new set of building blocks and assembly principles relevant to materials science, molecular biology, nanotechnology and precision medicine. The self-assembly of biomimetic peptides can mimic complex natural systems involving whole proteins. This Review describes how synthetic peptides afford tunable scaffolds for biomineralization, drug delivery and tissue growth.read more
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Journal ArticleDOI
A Global Review on Short Peptides: Frontiers and Perspectives.
Vasso Apostolopoulos,Joanna Bojarska,Tsun-Thai Chai,Sherif M. Elnagdy,Krzysztof Kaczmarek,John Matsoukas,John Matsoukas,Roger New,Keykavous Parang,Octavio Paredes Lopez,Hamideh Parhiz,Conrad O. Perera,Mónica Pickholz,Mónica Pickholz,Milan Remko,Michele Saviano,Mariusz Skwarczynski,Yefeng Tang,Wojciech M. Wolf,Taku Yoshiya,Janusz Zabrocki,Piotr Zielenkiewicz,Piotr Zielenkiewicz,Maha AlKhazindar,Vanessa Barriga,Konstantinos Kelaidonis,Elham Mousavinezhad Sarasia,Istvan Toth +27 more
TL;DR: In this article, the authors present a review of peptide-based therapeutics, focusing on the current state-of-the-art short peptidebased therapeutical developments, as a celebration of 100 years peptide therapeutics since the commencement of insulin therapy in the 1920s.
Journal ArticleDOI
Peptide-based nanomaterials: Self-assembly, properties and applications
Jie Jiang,Tong Li,Tong Li,Xianmao Lu,Xianmao Lu,Ming-Rong Zhang,Kuan Hu,Kuan Hu,Zhou Li,Zhou Li +9 more
TL;DR: In this paper, the authors provide a review of peptide-based self-assembly nanostructures, focusing on the driving forces that dominate peptide selfassembly and assembly mechanisms of peptides.
Journal ArticleDOI
NBD-based synthetic probes for sensing small molecules and proteins: design, sensing mechanisms and biological applications
Chenyang Jiang,Haojie Huang,Xueying Kang,Liu Yang,Zhen Xi,Hongyan Sun,Michael D. Pluth,Long Yi +7 more
TL;DR: A comprehensive review of NBD-based synthetic probes for biomolecular sensing can be found in this paper, where the authors discuss the sensing mechanisms and selectivity of the probes, the design strategies for multi-reactable multi-quenching probes, and the associated biological applications of these important constructs.
Journal ArticleDOI
Chemical syntheses of bioinspired and biomimetic polymers toward biobased materials
TL;DR: A review of recent progress in bio-inspired and biomimetic polymers and insights into biobased materials through the evolution of chemical approaches, including networking/crosslinking, dynamic interactions and self-assembly is presented in this paper.
References
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Journal ArticleDOI
A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD
Alan E. Renton,Elisa Majounie,Adrian James Waite,Javier Simón-Sánchez,Javier Simón-Sánchez,Sara Rollinson,J. Raphael Gibbs,J. Raphael Gibbs,Jennifer C. Schymick,Hannu Laaksovirta,John C. van Swieten,John C. van Swieten,Liisa Myllykangas,Hannu Kalimo,Anders Paetau,Yevgeniya Abramzon,Anne M. Remes,Alice Kaganovich,Sonja W. Scholz,Sonja W. Scholz,Sonja W. Scholz,Jamie Duckworth,Jinhui Ding,Daniel W. Harmer,Dena G. Hernandez,Dena G. Hernandez,Janel O. Johnson,Janel O. Johnson,Kin Y. Mok,Mina Ryten,Danyah Trabzuni,Rita Guerreiro,Richard W. Orrell,James Neal,Alexandra Murray,J. P. Pearson,Iris E. Jansen,David Sondervan,Harro Seelaar,Derek J. Blake,Kate Young,Nicola Halliwell,Janis Bennion Callister,Greg Toulson,Anna Richardson,Alexander Gerhard,Julie S. Snowden,David M. A. Mann,David Neary,Mike A. Nalls,Terhi Peuralinna,Lilja Jansson,Veli-Matti Isoviita,Anna-Lotta Kaivorinne,Maarit Hölttä-Vuori,Elina Ikonen,Raimo Sulkava,Michael Benatar,Joanne Wuu,Adriano Chiò,Gabriella Restagno,Giuseppe Borghero,Mario Sabatelli,David Heckerman,Ekaterina Rogaeva,Lorne Zinman,Jeffrey D. Rothstein,Michael Sendtner,Carsten Drepper,Evan E. Eichler,Can Alkan,Ziedulla Abdullaev,Svetlana Pack,Amalia Dutra,Evgenia Pak,John Hardy,Andrew B. Singleton,Nigel Williams,Peter Heutink,Stuart Pickering-Brown,Huw R. Morris,Huw R. Morris,Huw R. Morris,Pentti J. Tienari,Bryan J. Traynor,Bryan J. Traynor +85 more
TL;DR: The chromosome 9p21 amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD) locus contains one of the last major unidentified autosomal-dominant genes underlying these common neurodegenerative diseases, and a large hexanucleotide repeat expansion in the first intron of C9ORF72 is shown.
Journal ArticleDOI
Biomolecular condensates: organizers of cellular biochemistry
TL;DR: This work has shown that liquid–liquid phase separation driven by multivalent macromolecular interactions is an important organizing principle for biomolecular condensates and has proposed a physical framework for this organizing principle.