Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS)
Jean Pascal Lefaucheur,Andrea Antal,Samar S. Ayache,David H. Benninger,Jerome Brunelin,Filippo Cogiamanian,Maria Cotelli,Dirk De Ridder,Roberta Ferrucci,Berthold Langguth,Paola Marangolo,Veit Mylius,Michael A. Nitsche,Frank Padberg,Ulrich Palm,Emmanuel Poulet,Alberto Priori,Simone Rossi,Martin Schecklmann,Sven Vanneste,Ulf Ziemann,Luis Garcia-Larrea,Walter Paulus +22 more
TLDR
It remains to be clarified whether the probable or possible therapeutic effects of tDCS are clinically meaningful and how to optimally perform tDCS in a therapeutic setting.About:
This article is published in Clinical Neurophysiology.The article was published on 2017-01-01 and is currently open access. It has received 1062 citations till now. The article focuses on the topics: Transcranial direct-current stimulation & Dorsolateral prefrontal cortex.read more
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Acceptability of tDCS in treating stress-related mental health disorders: a mixed methods study among military patients and caregivers
TL;DR: In this paper, the authors investigated the acceptability of transcranial direct current stimulation (tDCS) for patients with stress-related mental health disorders, including posttraumatic stress disorder, anxiety, and impulsive aggression.
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Non-invasive and invasive brain stimulation in alcohol use disorders: A critical review of selected human evidence and methodological considerations to guide future research
Redwan Maatoug,K. Bihan,Philibert Duriez,P. Podevin,L. Silveira-Reis-Brito,A. Benyamina,Antoni Valero-Cabré,Bruno Millet +7 more
TL;DR: In this paper, the authors conducted a broad and systematic search on four electronic databases: NCBI PubMed, Web of Science, Handbooks and the Cochrane Library and found that the dorsolateral prefrontral cortex (DLPFC) is a promising target for treating alcohol use disorder.
Journal ArticleDOI
Transcranial electrical stimulation: How can a simple conductor orchestrate complex brain activity?
TL;DR: In this article , the authors argue that the direct effects of tES are not so mysterious: Extensive data from a wide range of model systems shows it has appreciable effects on the activity of individual neurons.
Journal ArticleDOI
Effects of non-invasive brain stimulation in children and young people with psychiatric disorders: a protocol for a systematic review.
Abstract: Most psychiatric disorders have their onset in childhood or adolescence, and if not fully treated have the potential for causing life-long psycho-social and physical sequelae. Effective psychotherapeutic and medication treatments exist, but a significant proportion of children and young people do not make a full recovery. Thus, novel, safe, brain-based alternatives or adjuncts to conventional treatments are needed. Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) are non-invasive brain stimulation (NIBS) techniques which have shown clinical benefits in adult psychiatric conditions. However, in children and young people their efficacy is not well established. The objective of this study will be to systematically evaluate the evidence on clinical effects of NIBS in children and young people with psychiatric disorders, assessing disorder-specific symptoms, mood and neurocognitive functions. We designed and registered a study protocol for a systematic review. We will include randomised and non-randomised controlled trials and observational studies (e.g. cohort, case-control, case series) assessing the effects of NIBS in children and young people (aged ≤ 24 years old) for psychiatric disorders. The primary outcome will be reduction of disorder-specific symptoms. Secondary outcomes will include effects on mood and cognition. A comprehensive search from database inception onwards will be conducted in MEDLINE, EMBASE and PsycINFO. Grey literature will be identified through searching multiple clinical trial registries. Two reviewers will independently screen all citations, full-text articles and abstract data. The methodological quality of the studies will be appraised using appropriate tools. We will provide a narrative synthesis of the evidence and according to heterogeneity will conduct an appropriate meta-analysis. Additional analyses will be conducted to explore the potential sources of heterogeneity. This systematic review will provide a broad and comprehensive evaluation of the evidence on clinical effects of NIBS in children and young people with psychiatric disorders. Our findings will be reported according to the PRISMA guidelines and will be of interest to multiple audiences (including patients, researchers, healthcare professionals and policy-makers). Results will be published in a peer-reviewed journal. PROSPERO CRD42019158957
Journal ArticleDOI
Extended fMRI-Guided Anodal and Cathodal Transcranial Direct Current Stimulation Targeting Perilesional Areas in Post-Stroke Aphasia: A Pilot Randomized Clinical Trial
Leora R. Cherney,Edna M. Babbitt,Edna M. Babbitt,Xue Wang,Laura L. Pitts,Laura L. Pitts,Laura L. Pitts +6 more
TL;DR: In this paper, the authors explored the safety and efficacy of fMRI-guided tDCS on functional language and cortical activity when delivered to the lesioned left hemisphere concurrently with SLT across an extended, six-week treatment period.
References
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Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation.
Michael A. Nitsche,Walter Paulus +1 more
TL;DR: Transcranial electrical stimulation using weak current may be a promising tool to modulate cerebral excitability in a non‐invasive, painless, reversible, selective and focal way.
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Neuroinflammation in Alzheimer's disease
Michael T. Heneka,Monica J. Carson,Joseph El Khoury,Gary E. Landreth,Frederic Brosseron,Douglas L. Feinstein,Andreas H. Jacobs,Tony Wyss-Coray,Tony Wyss-Coray,Javier Vitorica,Richard M. Ransohoff,Karl Herrup,Sally A. Frautschy,Bente Finsen,Guy C. Brown,Alexei Verkhratsky,Alexei Verkhratsky,Alexei Verkhratsky,Koji Yamanaka,Jari Koistinaho,Eicke Latz,Eicke Latz,Annett Halle,Gabor C. Petzold,Terrence Town,Dave Morgan,Mari L. Shinohara,V. Hugh Perry,Clive Holmes,Clive Holmes,Nicolas G. Bazan,David J. Brooks,Stéphane Hunot,Bertrand Joseph,Nikolaus Deigendesch,Olga Garaschuk,Erik Boddeke,Charles A. Dinarello,John C.S. Breitner,Greg M. Cole,Douglas T. Golenbock,Markus P. Kummer +41 more
TL;DR: Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction.
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Publication bias in clinical research
TL;DR: The presence of publication bias in a cohort of clinical research studies is confirmed and it is suggested that conclusions based only on a review of published data should be interpreted cautiously, especially for observational studies.
Book
Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex
TL;DR: The development of stimulus selectivity in the primary sensory cortex of higher vertebrates is considered in a general mathematical framework and a synaptic evolution scheme of a new kind is proposed in which incoming patterns rather than converging afferents compete.
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Drug Addiction and Its Underlying Neurobiological Basis: Neuroimaging Evidence for the Involvement of the Frontal Cortex
Rita Z. Goldstein,Nora D. Volkow +1 more
TL;DR: An integrated model of drug addiction that encompasses intoxication, bingeing, withdrawal, and craving is proposed, and results imply that addiction connotes cortically regulated cognitive and emotional processes, which result in the overvaluing of drug reinforcers, the undervalued of alternative rein forcers, and deficits in inhibitory control for drug responses.
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Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation.
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Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS)
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