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Open AccessJournal ArticleDOI

Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS)

Jean Pascal Lefaucheur, +22 more
- 01 Jan 2017 - 
- Vol. 128, Iss: 1, pp 56-92
TLDR
It remains to be clarified whether the probable or possible therapeutic effects of tDCS are clinically meaningful and how to optimally perform tDCS in a therapeutic setting.
About: 
This article is published in Clinical Neurophysiology.The article was published on 2017-01-01 and is currently open access. It has received 1062 citations till now. The article focuses on the topics: Transcranial direct-current stimulation & Dorsolateral prefrontal cortex.

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Journal ArticleDOI

Sham tDCS: A hidden source of variability? Reflections for further blinded, controlled trials.

Clara Fonteneau, +17 more
- 01 May 2019 - 
TL;DR: A multiplicity of sham stimulation protocols is being used in the tDCS research field and might have different biological effects beyond the intended transient sensations and it is sought to enlighten the scientific community to this possible confounding factor in order to increase reproducibility of neurophysiological, cognitive and clinical tDCS studies.
Journal ArticleDOI

Towards unravelling task-related modulations of neuroplastic changes induced in the human motor cortex

Daniella Terney, +2 more
- 01 Jul 2008 - 
TL;DR: The results show that transcranial direct current stimulation-induced plasticity is highly dependent on the state of the subject during stimulation, which was lower after both anodal and cathodal stimulation, compared with the passive condition.
Journal ArticleDOI

Fatigue in multiple sclerosis – Insights into evaluation and management

Samar S. Ayache, +2 more
- 01 Apr 2017 - 
TL;DR: The definition of MS fatigue is revisited, an overview of its pathophysiology is provided, and its clinical, structural and functional correlates are reappraised, along with a "road map" to facilitate the diagnosis and guide the therapeutic regimens of this multifactorial and multidimensional construct.
Journal ArticleDOI

Neurotechnology-aided interventions for upper limb motor rehabilitation in severe chronic stroke.

Martina Coscia, +11 more
- 01 Aug 2019 - 
TL;DR: How use of neurotechnologies within precision stroke medicine, home-based interventions, and novel clinical trial designs can enhance rehabilitative outcomes is discussed.
Journal ArticleDOI

Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology

Harald Hampel, +43 more
- 01 Jan 2018 - 
TL;DR: The goals are to identify common biological denominators or differentiating classifiers across the continuum of ND during detectable stages of pathophysiological progression, characterize systems-based intermediate endophenotypes, validate multi-modal novel diagnostic systems biomarkers, and advance clinical intervention trial designs by utilizing systems- based intermediate end phenotypes and candidate surrogate markers.
References
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Journal ArticleDOI

Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation.

Michael A. Nitsche, +1 more
- 01 Sep 2000 - 
TL;DR: Transcranial electrical stimulation using weak current may be a promising tool to modulate cerebral excitability in a non‐invasive, painless, reversible, selective and focal way.
Journal ArticleDOI

Neuroinflammation in Alzheimer's disease

Michael T. Heneka, +41 more
- 01 Apr 2015 - 
TL;DR: Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction.
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Publication bias in clinical research

P.J Easterbrook, +3 more
- 13 Apr 1991 - 
TL;DR: The presence of publication bias in a cohort of clinical research studies is confirmed and it is suggested that conclusions based only on a review of published data should be interpreted cautiously, especially for observational studies.
Book

Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex

Elie Bienenstock, +2 more
TL;DR: The development of stimulus selectivity in the primary sensory cortex of higher vertebrates is considered in a general mathematical framework and a synaptic evolution scheme of a new kind is proposed in which incoming patterns rather than converging afferents compete.
Journal ArticleDOI

Drug Addiction and Its Underlying Neurobiological Basis: Neuroimaging Evidence for the Involvement of the Frontal Cortex

Rita Z. Goldstein, +1 more
- 01 Oct 2002 - 
TL;DR: An integrated model of drug addiction that encompasses intoxication, bingeing, withdrawal, and craving is proposed, and results imply that addiction connotes cortically regulated cognitive and emotional processes, which result in the overvaluing of drug reinforcers, the undervalued of alternative rein forcers, and deficits in inhibitory control for drug responses.
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