FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.
Zuzana Tothova,Zuzana Tothova,Ramya Kollipara,Brian J. P. Huntly,Benjamin H. Lee,Benjamin H. Lee,Diego H. Castrillon,Dana E. Cullen,Dana E. Cullen,Elizabeth P. McDowell,Elizabeth P. McDowell,Suzan Lazo-Kallanian,Ifor R. Williams,Christopher Sears,Scott A. Armstrong,Emmanuelle Passegué,Ronald A. DePinho,D. Gary Gilliland,D. Gary Gilliland +18 more
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TLDR
FoxO proteins play essential roles in the response to physiologic oxidative stress and thereby mediate quiescence and enhanced survival in the HSC compartment, a function that is required for its long-term regenerative potential.About:
This article is published in Cell.The article was published on 2007-01-26 and is currently open access. It has received 1511 citations till now. The article focuses on the topics: FOXO Family & Hematopoietic stem cell.read more
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Resveratrol Prevention of Oxidative Stress Damage to Lens Epithelial Cell Cultures Is Mediated by Forkhead Box O Activity
Guorong Li,Coralia Luna,Iris Navarro,David L. Epstein,Wei Huang,Pedro Gonzalez,Pratap Challa +6 more
TL;DR: The levels of expression of FoxO1A, FoxO3A, and FoxO4 appear to play a central role in determining the pro- or anti-apoptotic effects of RES, which exerts a protective effect against oxidative damage in LEC cultures.
Journal ArticleDOI
A Distinct Reactive Oxygen Species Profile Confers Chemoresistance in Glioma-Propagating Cells and Associates with Patient Survival Outcome
Lynnette Koh,Geraldene Rong-Hui Koh,Felicia Soo Lee Ng,Tan Boon Toh,Edwin Sandanaraj,Yuk Kien Chong,Mark Phong,Greg Tucker-Kellogg,Oi Lian Kon,Wai Hoe Ng,Ivan Ng,Marie-Veronique Clement,Shazib Pervaiz,Beng Ti Ang,Carol Tang +14 more
TL;DR: In this article, the role of an elevated O2−:H2O2 ratio as a prosurvival signal in glioma-propagating cells (GPCs) was explored.
Journal ArticleDOI
Tight regulation of FOXO1 is essential for maintenance of B-cell precursor acute lymphoblastic leukemia.
Fan Wang,Salih Demir,Franziska Gehringer,Clarissa D. Osswald,Felix Seyfried,Stefanie Enzenmüller,SM Eckhoff,Thomas Maier,Karlheinz Holzmann,Klaus-Michael Debatin,Thomas Wirth,Lüder Hinrich Meyer,Alexey Ushmorov +12 more
TL;DR: Pharmacological inhibition of FOXO1 showed antileukemia activity on several primary, patient-derived, pediatric ALL xenografts with effective leukemia reduction in the hematopoietic, lymphoid, and central nervous system organ compartments, ultimately leading to prolonged survival without leukemia reoccurrence in a preclinical in vivo model of BCP-ALL.
Journal ArticleDOI
Mechanistic / mammalian target protein of rapamycin signaling in hematopoietic stem cells and leukemia
Atsushi Hirao,Takayuki Hoshii +1 more
TL;DR: Advances in understanding of how mTOR signaling is involved in mechanisms of normal HSC and LSC homeostasis may lead to novel therapeutic approaches that can successfully eradicate leukemia.
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Cellular and Molecular Mechanisms of Environmental Pollutants on Hematopoiesis.
Pablo Scharf,Milena Fronza Broering,Gustavo Henrique Oliveira da Rocha,Sandra Helena Poliselli Farsky +3 more
TL;DR: This review aims to describe the most recently investigated molecular and cellular toxicity mechanisms of current major environmental pollutants on hematopoiesis in the bone marrow.
References
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Aravind Subramanian,Pablo Tamayo,Vamsi K. Mootha,Sayan Mukherjee,Benjamin L. Ebert,Michael A. Gillette,Amanda G. Paulovich,Scott L. Pomeroy,Todd R. Golub,Eric S. Lander,Jill P. Mesirov +10 more
TL;DR: The Gene Set Enrichment Analysis (GSEA) method as discussed by the authors focuses on gene sets, that is, groups of genes that share common biological function, chromosomal location, or regulation.
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Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
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TL;DR: It is demonstrated that Akt also regulates the activity of FKHRL1, a member of the Forkhead family of transcription factors, which triggers apoptosis most likely by inducing the expression of genes that are critical for cell death, such as the Fas ligand gene.
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TL;DR: It is shown that rapamycin inhibits the assembly of mTORC2 and that, in many cell types, prolongedRapamycin treatment reduces the levels of m TORC2 below those needed to maintain Akt/PKB signaling.
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A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
TL;DR: The prospective identification, purification and characterization, using cell-surface markers and flow cytometry, of a complementary clonogenic common myeloid progenitor that gives rise to all myeloids lineages is reported.
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Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
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