FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.
Zuzana Tothova,Zuzana Tothova,Ramya Kollipara,Brian J. P. Huntly,Benjamin H. Lee,Benjamin H. Lee,Diego H. Castrillon,Dana E. Cullen,Dana E. Cullen,Elizabeth P. McDowell,Elizabeth P. McDowell,Suzan Lazo-Kallanian,Ifor R. Williams,Christopher Sears,Scott A. Armstrong,Emmanuelle Passegué,Ronald A. DePinho,D. Gary Gilliland,D. Gary Gilliland +18 more
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TLDR
FoxO proteins play essential roles in the response to physiologic oxidative stress and thereby mediate quiescence and enhanced survival in the HSC compartment, a function that is required for its long-term regenerative potential.About:
This article is published in Cell.The article was published on 2007-01-26 and is currently open access. It has received 1511 citations till now. The article focuses on the topics: FOXO Family & Hematopoietic stem cell.read more
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Mechanisms of self-renewal in hematopoietic stem cells
Zhao Wang,Hideo Ema +1 more
TL;DR: This review focuses on the HSC niche, the cytokine network, and associated transcription factors; and discusses to what extent the authors can currently understand these critical issues in stem cell biology.
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Impaired functionality and homing of Fancg-deficient hematopoietic stem cells
Vilma Barroca,Marc André Mouthon,Daniel Lewandowski,Philippe Brunet de la Grange,Laurent Gauthier,Françoise Pflumio,François D. Boussin,Fré Arwert,Lydia Riou,Isabelle Allemand,Paul-Henri Romeo,Pierre Fouchet +11 more
TL;DR: The data reveal that Fancg should play a role in the regulation of physiological functions of HSC, and the expression of several key genes involved in self-renewal, quiescence and migration of H SC was dysregulated in Fanc g-deficient LSK subset.
Journal ArticleDOI
Vitamin D Receptor Controls Cell Stemness in Acute Myeloid Leukemia and in Normal Bone Marrow
Etienne Paubelle,Florence Zylbersztejn,Florence Zylbersztejn,Florence Zylbersztejn,Thiago Trovati Maciel,Caroline Carvalho,Annalisa Mupo,Meyling Cheok,Liesbet Lieben,Pierre Sujobert,Pierre Sujobert,Justine Decroocq,Justine Decroocq,Justine Decroocq,Akihiko Yokoyama,Vahid Asnafi,Elizabeth Macintyre,Jerome Tamburini,Jerome Tamburini,Valérie Bardet,Valérie Bardet,Valérie Bardet,Sylvie Castaigne,Claude Preudhomme,Hervé Dombret,Geert Carmeliet,Didier Bouscary,Didier Bouscary,Yelena Ginzburg,Marc Benhamou,Renato C. Monteiro,George S. Vassiliou,Olivier Hermine,Ivan C. Moura +33 more
TL;DR: An unexpected role of VDR in normal hematopoiesis and in leukemogenesis is presented and it is shown that Vdr functions as a regulator of stem cell homeostasis and leukemic propagation.
Journal ArticleDOI
Regulation of Hematopoiesis and Hematological Disease by TGF-β Family Signaling Molecules
Kazuhito Naka,Atsushi Hirao +1 more
TL;DR: The paradox that, although intrinsic TGF-β signaling is essential for regulating the survival and resistance to therapy of chronic myelogenous leukemia (CML) stem cells, genetic changes that abrogate TGF -β signaling can lead to the development of several hematological malignancies is examined.
References
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Aravind Subramanian,Pablo Tamayo,Vamsi K. Mootha,Sayan Mukherjee,Benjamin L. Ebert,Michael A. Gillette,Amanda G. Paulovich,Scott L. Pomeroy,Todd R. Golub,Eric S. Lander,Jill P. Mesirov +10 more
TL;DR: The Gene Set Enrichment Analysis (GSEA) method as discussed by the authors focuses on gene sets, that is, groups of genes that share common biological function, chromosomal location, or regulation.
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Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
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TL;DR: It is demonstrated that Akt also regulates the activity of FKHRL1, a member of the Forkhead family of transcription factors, which triggers apoptosis most likely by inducing the expression of genes that are critical for cell death, such as the Fas ligand gene.
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TL;DR: It is shown that rapamycin inhibits the assembly of mTORC2 and that, in many cell types, prolongedRapamycin treatment reduces the levels of m TORC2 below those needed to maintain Akt/PKB signaling.
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A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
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Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
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