FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.
Zuzana Tothova,Zuzana Tothova,Ramya Kollipara,Brian J. P. Huntly,Benjamin H. Lee,Benjamin H. Lee,Diego H. Castrillon,Dana E. Cullen,Dana E. Cullen,Elizabeth P. McDowell,Elizabeth P. McDowell,Suzan Lazo-Kallanian,Ifor R. Williams,Christopher Sears,Scott A. Armstrong,Emmanuelle Passegué,Ronald A. DePinho,D. Gary Gilliland,D. Gary Gilliland +18 more
Reads0
Chats0
TLDR
FoxO proteins play essential roles in the response to physiologic oxidative stress and thereby mediate quiescence and enhanced survival in the HSC compartment, a function that is required for its long-term regenerative potential.About:
This article is published in Cell.The article was published on 2007-01-26 and is currently open access. It has received 1511 citations till now. The article focuses on the topics: FOXO Family & Hematopoietic stem cell.read more
Citations
More filters
Journal ArticleDOI
DNA damage accumulation and repair defects in acute myeloid leukemia: implications for pathogenesis, disease progression, and chemotherapy resistance
TL;DR: The current review summarizes the DDR pathways in the context of AML and describes how aberrant DNA damage response can affect AML pathogenesis, disease progression, and resistance to standard chemotherapy, and how defects in DDR pathways may provide a new avenue for personalized therapeutic strategies in AML.
Journal ArticleDOI
Interplay of dFOXO and two ETS-family transcription factors determines lifespan in Drosophila melanogaster.
Nazif Alic,MMaria Giannakou,Irene Papatheodorou,Matthew P. Hoddinott,Thomas Daniel Andrews,Ekin Bolukbasi,Linda Partridge +6 more
TL;DR: A complex interplay between evolutionarily conserved ETS factors and dFOXO is revealed, the functional significance of which may extend well beyond animal lifespan.
Journal ArticleDOI
Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms.
Heather A. Himburg,Phuong L. Doan,Mamle Quarmyne,Mamle Quarmyne,Xiao Yan,Xiao Yan,Joshua P. Sasine,Liman Zhao,Grace V. Hancock,Jenny Kan,Katherine Pohl,Evelyn Tran,Nelson J. Chao,Jeffrey R. Harris,John P. Chute +14 more
TL;DR: Deletion of the pro-apoptotic genes Bak and Bax in Osx in osterix cells in mice promotes HSC regeneration and hematopoietic radioprotection following total body irradiation and demonstrates paracrine cross-talk between BM osteolineage cells and endothelial cells in regulating hematopolietic reconstitution following injury.
Journal ArticleDOI
Pharmacological Regulation of Oxidative Stress in Stem Cells
TL;DR: The defined roles of oxidative Stress in pluripotent stem cells and hematopoietic stem cells are introduced and the potential applications of pharmacological approaches for regulating oxidative stress in regenerative medicine are discussed.
Journal ArticleDOI
The role of autophagy in neonatal tissues: just a response to amino acid starvation?
TL;DR: Autophagy is activated soon after birth in neonatal tissues and is essential for survival because mice deficient in Atg5 or Atg7 autophagy genes die within 1 day after birth, but may have other important functions in Neonatal physiology, including glycogen degradation, programmed cell remodeling and response to oxidative stress.
References
More filters
Journal ArticleDOI
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
Aravind Subramanian,Pablo Tamayo,Vamsi K. Mootha,Sayan Mukherjee,Benjamin L. Ebert,Michael A. Gillette,Amanda G. Paulovich,Scott L. Pomeroy,Todd R. Golub,Eric S. Lander,Jill P. Mesirov +10 more
TL;DR: The Gene Set Enrichment Analysis (GSEA) method as discussed by the authors focuses on gene sets, that is, groups of genes that share common biological function, chromosomal location, or regulation.
Journal ArticleDOI
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Anne Brunet,Azad Bonni,Michael J. Zigmond,Michael Z. Lin,Peter Juo,Linda Hu,Michael J. Anderson,Karen C. Arden,John Blenis,Michael E. Greenberg +9 more
TL;DR: It is demonstrated that Akt also regulates the activity of FKHRL1, a member of the Forkhead family of transcription factors, which triggers apoptosis most likely by inducing the expression of genes that are critical for cell death, such as the Fas ligand gene.
Journal ArticleDOI
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.
Dos D. Sarbassov,Siraj M. Ali,Siraj M. Ali,Shomit Sengupta,Shomit Sengupta,Joon Ho Sheen,Joon Ho Sheen,Peggy P. Hsu,Peggy P. Hsu,Alex F. Bagley,Alex F. Bagley,Andrew L. Markhard,Andrew L. Markhard,David M. Sabatini,David M. Sabatini +14 more
TL;DR: It is shown that rapamycin inhibits the assembly of mTORC2 and that, in many cell types, prolongedRapamycin treatment reduces the levels of m TORC2 below those needed to maintain Akt/PKB signaling.
Journal ArticleDOI
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
TL;DR: The prospective identification, purification and characterization, using cell-surface markers and flow cytometry, of a complementary clonogenic common myeloid progenitor that gives rise to all myeloids lineages is reported.
Journal ArticleDOI
Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
TL;DR: The Lin(-)IL-7R(+)Thy-1(-)Sca-1loc-Kit(lo) population from adult mouse bone marrow possessed a rapid lymphoid-restricted (T, B, and NK) reconstitution capacity in vivo but completely lacked myeloid differentiation potential either in vivo or in vitro.