FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.
Zuzana Tothova,Zuzana Tothova,Ramya Kollipara,Brian J. P. Huntly,Benjamin H. Lee,Benjamin H. Lee,Diego H. Castrillon,Dana E. Cullen,Dana E. Cullen,Elizabeth P. McDowell,Elizabeth P. McDowell,Suzan Lazo-Kallanian,Ifor R. Williams,Christopher Sears,Scott A. Armstrong,Emmanuelle Passegué,Ronald A. DePinho,D. Gary Gilliland,D. Gary Gilliland +18 more
Reads0
Chats0
TLDR
FoxO proteins play essential roles in the response to physiologic oxidative stress and thereby mediate quiescence and enhanced survival in the HSC compartment, a function that is required for its long-term regenerative potential.About:
This article is published in Cell.The article was published on 2007-01-26 and is currently open access. It has received 1511 citations till now. The article focuses on the topics: FOXO Family & Hematopoietic stem cell.read more
Citations
More filters
Journal ArticleDOI
Zebrafish eaf1 suppresses foxo3b expression to modulate transcriptional activity of gata1 and spi1 in primitive hematopoiesis
TL;DR: It is shown that knockdown of zebrafish eaf1 by morpholinos caused serious defects in both primitive and definitive hematopoiesis, and a novel regulatory pathway is revealed that may shed light on the role of EAF1 in MLL-ELL induced leukemogenesis.
Journal ArticleDOI
New light on the biology and developmental potential of haematopoietic stem cells and progenitor cells.
TL;DR: In this review, several of the basic features of HSCs, as well as their multipotent and lineage‐restricted offspring, are addressed, providing a current view of the haematopoietic development tree.
Journal ArticleDOI
Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality
TL;DR: Using cellular barcoding, this work found that calreticulin knock-down or embryonic macrophage depletion reduced the number of stem cell clones that established adult hematopoiesis, which supports a model in which embryonic Macrophages determine hematoietic clonality by monitoring stem cell quality.
Journal ArticleDOI
Signaling Pathways Regulating Hematopoietic Stem Cell and Progenitor Aging
TL;DR: Current understanding of the signaling pathways that are differentially activated or repressed during HSC/P aging are reviewed, focusing on the oxidative, metabolic, biochemical, and structural consequences downstream, and cell-intrinsic, systemic, and environmental influences.
Posted ContentDOI
PDGFRα signaling in cardiac stem and stromal cells modulates quiescence, metabolism and self-renewal, and promotes anatomical and functional repair
Richard P. Harvey,Naisnana S Asili,Munira Xaymardan,Elvira Forte,Ashley J. Waardenberg,James Cornwell,Vaibhao Janbandhu,Scott H. Kesteven,Vashe Chandrakanthan,Helena Malinowska,Henrik Reinhard,Sile Yang,Hilda A. Pickett,Peter R. Schofield,Daniel Christ,Ishtiaq Ahmed,James J.H. Chong,Corey Heffernan,Joan Li,Mary Simonian,Romaric Bouveret,Surabhi Srivastava,Rakesh Mishra,Jyotsna Dhawan,Robert E. Nordon,Peter S. Macdonald,Robert M. Graham,Michael P. Feneley +27 more
TL;DR: In this paper, the role of platelet derived growth factor receptor α (PDGFRα) in cardiac colony forming units (cCFU-F) and S+P+ cell niche regulation in homeostasis and repair was explored.
References
More filters
Journal ArticleDOI
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
Aravind Subramanian,Pablo Tamayo,Vamsi K. Mootha,Sayan Mukherjee,Benjamin L. Ebert,Michael A. Gillette,Amanda G. Paulovich,Scott L. Pomeroy,Todd R. Golub,Eric S. Lander,Jill P. Mesirov +10 more
TL;DR: The Gene Set Enrichment Analysis (GSEA) method as discussed by the authors focuses on gene sets, that is, groups of genes that share common biological function, chromosomal location, or regulation.
Journal ArticleDOI
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Anne Brunet,Azad Bonni,Michael J. Zigmond,Michael Z. Lin,Peter Juo,Linda Hu,Michael J. Anderson,Karen C. Arden,John Blenis,Michael E. Greenberg +9 more
TL;DR: It is demonstrated that Akt also regulates the activity of FKHRL1, a member of the Forkhead family of transcription factors, which triggers apoptosis most likely by inducing the expression of genes that are critical for cell death, such as the Fas ligand gene.
Journal ArticleDOI
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.
Dos D. Sarbassov,Siraj M. Ali,Siraj M. Ali,Shomit Sengupta,Shomit Sengupta,Joon Ho Sheen,Joon Ho Sheen,Peggy P. Hsu,Peggy P. Hsu,Alex F. Bagley,Alex F. Bagley,Andrew L. Markhard,Andrew L. Markhard,David M. Sabatini,David M. Sabatini +14 more
TL;DR: It is shown that rapamycin inhibits the assembly of mTORC2 and that, in many cell types, prolongedRapamycin treatment reduces the levels of m TORC2 below those needed to maintain Akt/PKB signaling.
Journal ArticleDOI
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
TL;DR: The prospective identification, purification and characterization, using cell-surface markers and flow cytometry, of a complementary clonogenic common myeloid progenitor that gives rise to all myeloids lineages is reported.
Journal ArticleDOI
Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
TL;DR: The Lin(-)IL-7R(+)Thy-1(-)Sca-1loc-Kit(lo) population from adult mouse bone marrow possessed a rapid lymphoid-restricted (T, B, and NK) reconstitution capacity in vivo but completely lacked myeloid differentiation potential either in vivo or in vitro.