FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.
Zuzana Tothova,Zuzana Tothova,Ramya Kollipara,Brian J. P. Huntly,Benjamin H. Lee,Benjamin H. Lee,Diego H. Castrillon,Dana E. Cullen,Dana E. Cullen,Elizabeth P. McDowell,Elizabeth P. McDowell,Suzan Lazo-Kallanian,Ifor R. Williams,Christopher Sears,Scott A. Armstrong,Emmanuelle Passegué,Ronald A. DePinho,D. Gary Gilliland,D. Gary Gilliland +18 more
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TLDR
FoxO proteins play essential roles in the response to physiologic oxidative stress and thereby mediate quiescence and enhanced survival in the HSC compartment, a function that is required for its long-term regenerative potential.About:
This article is published in Cell.The article was published on 2007-01-26 and is currently open access. It has received 1511 citations till now. The article focuses on the topics: FOXO Family & Hematopoietic stem cell.read more
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Mitoquinone restores platelet production in irradiation-induced thrombocytopenia.
TL;DR: Investigation shows that mice lacking immediate early responsive gene X-1 (IEX-1) exhibit lineage specific increases in ROS production and abnormal cytology upon radiation in blood cell types commonly identified in MDS, which may help understand the etiology of thrombocytopenia in association with MDS in a subgroup of the patients.
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Parthenolide and DMAPT induce cell death in primitive CML cells through reactive oxygen species
Gabriela Flores‐Lopez,Dafne Moreno-Lorenzana,Manuel Ayala-Sánchez,Sócrates Avilés-Vázquez,Hector Torres-Martinez,Peter A. Crooks,Monica L. Guzman,Hector Mayani,Antonieta Chávez-González +8 more
TL;DR: It is shown that PTL and DMAPT have a strong inhibitory effect on CML cells, and it is speculated that this effect could be a direct consequence of NF‐κB inhibition and if this mechanism was to be evaded, P TL andDMAPT induced cell death would be potentiated.
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The mirn23a and mirn23b microrna clusters are necessary for proper hematopoietic progenitor cell production and differentiation.
Jeffrey L. Kurkewich,Austin Boucher,Nathan Klopfenstein,Ramdas Baskar,Reuben Kapur,Richard Dahl,Richard Dahl +6 more
TL;DR: This paper showed that complete loss of mirn23a/mirn23b miRNAs results in decreased blood production and affects lineage output in a concentration-dependent manner, demonstrating a dosage-dependent effect on regulating cell differentiation.
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Structure and function of the solid tumor niche.
TL;DR: Current understanding of the HSC niche may provide more insight to better defining the solid tumor niche, and new insights to the role of the BMM in metastatic disease may be gained, and provide more potential targets for therapy.
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Reactive Oxygen Species Induce Endothelial Differentiation of Liver Cancer Stem-Like Sphere Cells through the Activation of Akt/IKK Signaling Pathway.
TL;DR: It is demonstrated that cancer stem-like sphere cells enriched from human hepatocellular carcinoma cell line Hep G2 are able to differentiate into endothelial cells both morphologically and functionally, and this process is independent of VEGF and NOTCH signaling but dependent on the activation of Akt and IKK.
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Aravind Subramanian,Pablo Tamayo,Vamsi K. Mootha,Sayan Mukherjee,Benjamin L. Ebert,Michael A. Gillette,Amanda G. Paulovich,Scott L. Pomeroy,Todd R. Golub,Eric S. Lander,Jill P. Mesirov +10 more
TL;DR: The Gene Set Enrichment Analysis (GSEA) method as discussed by the authors focuses on gene sets, that is, groups of genes that share common biological function, chromosomal location, or regulation.
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Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Anne Brunet,Azad Bonni,Michael J. Zigmond,Michael Z. Lin,Peter Juo,Linda Hu,Michael J. Anderson,Karen C. Arden,John Blenis,Michael E. Greenberg +9 more
TL;DR: It is demonstrated that Akt also regulates the activity of FKHRL1, a member of the Forkhead family of transcription factors, which triggers apoptosis most likely by inducing the expression of genes that are critical for cell death, such as the Fas ligand gene.
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TL;DR: It is shown that rapamycin inhibits the assembly of mTORC2 and that, in many cell types, prolongedRapamycin treatment reduces the levels of m TORC2 below those needed to maintain Akt/PKB signaling.
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A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
TL;DR: The prospective identification, purification and characterization, using cell-surface markers and flow cytometry, of a complementary clonogenic common myeloid progenitor that gives rise to all myeloids lineages is reported.
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Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
TL;DR: The Lin(-)IL-7R(+)Thy-1(-)Sca-1loc-Kit(lo) population from adult mouse bone marrow possessed a rapid lymphoid-restricted (T, B, and NK) reconstitution capacity in vivo but completely lacked myeloid differentiation potential either in vivo or in vitro.