FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.
Zuzana Tothova,Zuzana Tothova,Ramya Kollipara,Brian J. P. Huntly,Benjamin H. Lee,Benjamin H. Lee,Diego H. Castrillon,Dana E. Cullen,Dana E. Cullen,Elizabeth P. McDowell,Elizabeth P. McDowell,Suzan Lazo-Kallanian,Ifor R. Williams,Christopher Sears,Scott A. Armstrong,Emmanuelle Passegué,Ronald A. DePinho,D. Gary Gilliland,D. Gary Gilliland +18 more
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TLDR
FoxO proteins play essential roles in the response to physiologic oxidative stress and thereby mediate quiescence and enhanced survival in the HSC compartment, a function that is required for its long-term regenerative potential.About:
This article is published in Cell.The article was published on 2007-01-26 and is currently open access. It has received 1511 citations till now. The article focuses on the topics: FOXO Family & Hematopoietic stem cell.read more
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Erratum: The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response (Cell (2014) 157 (741-743))
Bao N. Puente,Wataru Kimura,Shalini Muralidhar,Jesung Moon,James F. Amatruda,Kate L. Phelps,David Grinsfelder,Beverly A. Rothermel,Rui Chen,Joseph A. Garcia,Celio X.C. Santos,Suwannee Thet,Eiichiro Mori,Michael Kinter,Paul M. Rindler,Serena Zacchigna,Shibani Mukherjee,David J. Chen,Ahmed I. Mahmoud,Mauro Giacca,Peter S. Rabinovitch,Aroumougame Asaithamby,Ajay M. Shah,Luke I. Szweda,Hesham A. Sadek +24 more
TL;DR: This cross-cultural study aimed at determining the carrier and removal status of canine coronavirus in mice shows clear signs of belonging to the “love-hate” group.
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Unravelling the tumor-suppressive functions of FOXO proteins
TL;DR: Recent advances in the understanding of the roles of FOXO family members in tumor suppression are discussed.
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Changes in primary lymphoid organs with aging
TL;DR: Mounting evidence argues that with aging, thymic inflammation, systemic stress, local Foxn1 and keratinocyte growth factor expression, and sex steroid levels play critical roles in actively driving thymi involution and overall adaptive immune senescence across the lifespan.
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Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing.
TL;DR: Recent advances in the understanding of the metabolic control of stem cell function, and how stem cell metabolism relates to homeostasis and ageing are discussed.
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DNA Damage in Stem Cells.
TL;DR: The pathophysiological and therapeutic implications of the molecular pathways through which stem cells cope with DNA damage are discussed.
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Aravind Subramanian,Pablo Tamayo,Vamsi K. Mootha,Sayan Mukherjee,Benjamin L. Ebert,Michael A. Gillette,Amanda G. Paulovich,Scott L. Pomeroy,Todd R. Golub,Eric S. Lander,Jill P. Mesirov +10 more
TL;DR: The Gene Set Enrichment Analysis (GSEA) method as discussed by the authors focuses on gene sets, that is, groups of genes that share common biological function, chromosomal location, or regulation.
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Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Anne Brunet,Azad Bonni,Michael J. Zigmond,Michael Z. Lin,Peter Juo,Linda Hu,Michael J. Anderson,Karen C. Arden,John Blenis,Michael E. Greenberg +9 more
TL;DR: It is demonstrated that Akt also regulates the activity of FKHRL1, a member of the Forkhead family of transcription factors, which triggers apoptosis most likely by inducing the expression of genes that are critical for cell death, such as the Fas ligand gene.
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Dos D. Sarbassov,Siraj M. Ali,Siraj M. Ali,Shomit Sengupta,Shomit Sengupta,Joon Ho Sheen,Joon Ho Sheen,Peggy P. Hsu,Peggy P. Hsu,Alex F. Bagley,Alex F. Bagley,Andrew L. Markhard,Andrew L. Markhard,David M. Sabatini,David M. Sabatini +14 more
TL;DR: It is shown that rapamycin inhibits the assembly of mTORC2 and that, in many cell types, prolongedRapamycin treatment reduces the levels of m TORC2 below those needed to maintain Akt/PKB signaling.
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A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
TL;DR: The prospective identification, purification and characterization, using cell-surface markers and flow cytometry, of a complementary clonogenic common myeloid progenitor that gives rise to all myeloids lineages is reported.
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Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
TL;DR: The Lin(-)IL-7R(+)Thy-1(-)Sca-1loc-Kit(lo) population from adult mouse bone marrow possessed a rapid lymphoid-restricted (T, B, and NK) reconstitution capacity in vivo but completely lacked myeloid differentiation potential either in vivo or in vitro.