Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study
Van-Mai Cao-Lormeau,Alexandre Blake,Sandrine Mons,Stéphane Lastère,Claudine Roche,Jessica Vanhomwegen,Timothée Dub,Laure Baudouin,Anita Teissier,P. Larre,Anne-Laure Vial,Christophe Decam,Valérie Choumet,Susan K. Halstead,Hugh J. Willison,Lucile Musset,Jean-Claude Manuguerra,Philippe Desprès,Emmanuel Fournier,Henri-Pierre Mallet,Didier Musso,Arnaud Fontanet,Arnaud Fontanet,Jean Neil,Frédéric Ghawché +24 more
TLDR
This is the first study providing evidence for Zika virus infection causing Guillain-Barré syndrome, and because Zika virus is spreading rapidly across the Americas, at risk countries need to prepare for adequate intensive care beds capacity to manage patients with Guillay-B Barré syndrome.About:
This article is published in The Lancet.The article was published on 2016-04-09 and is currently open access. It has received 1925 citations till now. The article focuses on the topics: Zika virus & Zika virus disease.read more
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In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus
Raimunda do Socorro da Silva Azevedo,Jorge Rodrigues de Sousa,Marialva Tereza Ferreira de Araújo,Arnaldo Jorge Martins Filho,Bianca Nascimento de Alcantara,Fernanda Montenegro de Carvalho Araújo,Maria G. L. Queiroz,Ana Cecília Ribeiro Cruz,Beatriz H. Baldez Vasconcelos,Jannifer Oliveira Chiang,Lívia Carício Martins,Livia Medeiros Neves Casseb,Eliana Vieira Pinto da Silva,Valéria Lima Carvalho,Barbara Cristina Baldez Vasconcelos,Sueli Rodrigues,Consuelo Silva de Oliveira,Juarez Antônio Simões Quaresma,Pedro Fernando da Costa Vasconcelos +18 more
TL;DR: The in situ immune response profile and mechanisms of neuronal cell damage in fatal Zika microcephaly cases were investigated and changes found were mainly calcification, necrosis, neuronophagy, gliosis, microglial nodules, and inflammatory infiltration of mononuclear cells.
Journal Article
[Guillain-Barré syndrome].
TL;DR: High-dose of intravenous immunoglobulin (0.4 g/kg daily for 5 days) and PE are equally effective in intermediate and severe forms and the choice between the two treatments depends on their respective contra-indications and local availability.
Journal ArticleDOI
The Brazilian Zika virus strain causes birth defects in experimental models
Fernanda R. Cugola,Isabella Rodrigues Fernandes,Isabella Rodrigues Fernandes,Fabiele Baldino Russo,Beatriz C.G. Freitas,João Leonardo Rodrigues Mendonça Dias,Katia de Oliveira Pimenta Guimarães,Cecilia Benazzato,Nathalia Almeida,Graciela Conceição Pignatari,Sarah Romero,Carolina Manganeli Polonio,Isabela Werneck da Cunha,Carla Longo de Freitas,Wesley Nogueira Brandão,Cristiano Rossato,David G. Andrade,Daniele de Paula Faria,Alexandre T. Garcez,Carlos Alberto Buchpigel,Carla Torres Braconi,Erica A. Mendes,Amadou A. Sall,Paolo Marinho de Andrade Zanotto,Jean Pierre Schatzmann Peron,Alysson R. Muotri,Patricia Cristina Baleeiro Beltrão-Braga +26 more
TL;DR: It is demonstrated that the ZIKVBR infects fetuses, causing intra-uterine growth restriction (IUGR), and crosses the placenta and causes microcephaly by targeting cortical progenitor cells, inducing cell death by apoptosis and autophagy, impairing neurodevelopment.
Journal ArticleDOI
Guillain-Barré syndrome.
TL;DR: The data for GBS suggests that the immunologic mechanism can involve molecular mimicry, at least in some GBS variants, and it is likely that multiple mechanisms render the axon vulnerable.
Journal ArticleDOI
Zika virus in the Americas: Early epidemiological and genetic findings
Nuno R. Faria,Nuno R. Faria,Raimunda do Socorro da Silva Azevedo,Moritz U. G. Kraemer,Renato Pereira de Souza,Mariana Sequetin Cunha,Sarah C. Hill,Julien Thézé,Michael B. Bonsall,Thomas A. Bowden,Ilona Rissanen,Iray Maria Rocco,Juliana Silva Nogueira,Adriana Yurika Maeda,Fernanda Giseli da Silva Vasami,F. L. L. Macedo,Akemi Suzuki,Sueli Guerreiro Rodrigues,Ana Cecília Ribeiro Cruz,Bruno Tardeli Nunes,Daniele Barbosa de Almeida Medeiros,Daniela Sueli Guerreiro Rodrigues,Alice Louize Nunes Queiroz,Eliana Vieira Pinto da Silva,Daniele Freitas Henriques,Elisabeth Salbe Travassos da Rosa,Consuelo Silva de Oliveira,Lívia Carício Martins,Helena Baldez Vasconcelos,Livia Medeiros Neves Casseb,Darlene B. Simith,Jane P. Messina,Leandro Abade,José Lourenço,Luiz Carlos Junior Alcantara,Maricélia Maia de Lima,Marta Giovanetti,Simon I. Hay,Simon I. Hay,Rodrigo Santos de Oliveira,Poliana da Silva Lemos,Layanna Freitas de Oliveira,Clayton Pereira Silva de Lima,Sandro Patroca da Silva,Janaina Mota de Vasconcelos,L. C Franco,Jedson Ferreira Cardoso,João Lídio Silva Gonçalves Vianez-Júnior,Daiana Mir,Gonzalo Bello,Edson Delatorre,Kamran Khan,Kamran Khan,Marisa I Creatore,Giovanini E. Coelho,Wanderson Kleber de Oliveira,Robert B. Tesh,Oliver G. Pybus,Márcio Roberto Teixeira Nunes,Márcio Roberto Teixeira Nunes,Pedro Fernando da Costa Vasconcelos +60 more
TL;DR: Results of phylogenetic and molecular clock analyses show a single introduction of ZikV into the Americas, which is estimated to have occurred between May and December 2013, more than 12 months before the detection of ZIKV in Brazil.
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