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Hydrogels for tissue engineering.
Kuen Yong Lee,David J. Mooney +1 more
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This article is published in Chemical Reviews.The article was published on 2001-05-31. It has received 4511 citations till now. The article focuses on the topics: Self-healing hydrogels.read more
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3D liver models on a microplatform: well-defined culture, engineering of liver tissue and liver-on-a-chip.
TL;DR: An overview of microtechnologies that have been used for liver studies are provided, biomimetic technologies for constructing microscale 2D and 3D liver models as well as liver-on-a-chip systems and microscale bioreactors are described, and applications of liver microtechnology are introduced and future trends in the field are introduced.
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Advances in smart materials: Stimuli‐responsive hydrogel thin films
TL;DR: This review highlights recent developments in the field of stimuli-responsive hydrogels, focusing primarily on thin films, with a thickness range between 100 nm to 10 μm, with the potential to advance the fields of medicine and polymer science as useful substrates for “smart” devices.
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Opportunities for Multicomponent Hybrid Hydrogels in Biomedical Applications
Hang Kuen Lau,Kristi L. Kiick +1 more
TL;DR: This review summarizes recent approaches aimed at producing multicomponent hydrogels, with descriptions of contemporary chemical and physical approaches for forming networks, and of the use of both synthetic and biologically derived molecules to impart desired properties.
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Simplifying the extracellular matrix for 3‐D cell culture and tissue engineering: A pragmatic approach
TL;DR: It is argued that the standard for 3‐D cell culture should be bio‐inspired, biomimetic materials that can be used “as is” in drug discovery, toxicology, cell banking, and ultimately in medicine, and one such material is described: a covalently crosslinked, biodegradable, simplified mimic of the extracellular matrix (ECM) that permits 3-D culture of cells in vitro and enables tissue formation in vivo.
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Mechanical properties of alginate hydrogels manufactured using external gelation.
TL;DR: This work describes the manufacture and characterisation of sodium alginate hydrogels using the divalent cations Mg(2+), Ca(2+) and Sr(2)+ to promote gelation via non-covalent crosslinks.
References
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Solution Properties of Poly(N-isopropylacrylamide)
M. Heskins,J. E. Guillet +1 more
TL;DR: In this paper, a lower critical solution temperature of poly(N-isopropyl acrylamide was found to be due to an entropy effect, which was attributed to the formation of nonpolar and intermolecular hydrogen bonds.
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Polymeric Systems for Controlled Drug Release
TL;DR: Kevin Shakesheff investigates new methods of engineering polymer surfaces and the application of these engineered materials in drug delivery and tissue engineering.
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Alginate hydrogels as synthetic extracellular matrix materials
TL;DR: Alginate may prove to be an ideal material with which to confer specific cellular interactive properties, potentially allowing for the control of long-term gene expression of cells within these matrices.
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Biodegradable block copolymers as injectable drug-delivery systems
TL;DR: The synthesis of a thermosensitive, biodegradable hydrogel consisting of blocks of poly(ethylene oxide) and poly(L-lactic acid) and aqueous solutions of these copolymers exhibit temperature-dependent reversible gel–sol transitions.