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Hydrogels for tissue engineering.
Kuen Yong Lee,David J. Mooney +1 more
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This article is published in Chemical Reviews.The article was published on 2001-05-31. It has received 4511 citations till now. The article focuses on the topics: Self-healing hydrogels.read more
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Osteogenic differentiation of rabbit mesenchymal stem cells in thermo-reversible hydrogel constructs containing hydroxyapatite and bone morphogenic protein-2 (BMP-2).
TL;DR: Combined MSC-seeded hybrid scaffold containing BMP-2 was a promising method by which to enhance in vitro osteogenic differentiation of MSC and in vivo ectopic bone formation.
Journal ArticleDOI
Self-healable, tough and highly stretchable ionic nanocomposite physical hydrogels
Ming Zhong,Xiao-Ying Liu,Fu-Kuan Shi,Li-Qin Zhang,Xi-Ping Wang,Andrew G. Cheetham,Honggang Cui,Xu-Ming Xie +7 more
TL;DR: The design rationale for the creation of ionic cross-linked hydrogels is to graft an acrylic acid monomer on the surface of vinyl hybrid silica nanoparticles for the growth of poly(acrylic) acid (PAA), and the obtained VSNP-PAA nanobrush can be used as a gelator.
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Self-assembled prodrugs: An enzymatically triggered drug-delivery platform
TL;DR: The ability of prodrugs to self-assemble to form hydrogels that could subsequently encapsulate a second drug such as curcumin, which is a known chemopreventive and anti-inflammatory hydrophobic drug, is shown.
Journal ArticleDOI
Controlling Degradation of Hydrogels via the Size of Cross-Linked Junctions.
TL;DR: A new approach to regulate the degradation kinetics of ionically crosslinked gels via controlling the dissociation rate of the polymer chains is introduced and the importance of controlling the degradation of these hydrogels to the formation of cartilage tissues that result from cell transplantation is demonstrated.
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Injectable, mixed natural-synthetic polymer hydrogels with modular properties.
Mathew Patenaude,Todd Hoare +1 more
TL;DR: A series of synthetic oligomers and carbohydrate polymers were functionalized with hydrazide or aldehyde functional groups and mixed using a double-barreled syringe to create in situ gelling, hydrazone-cross-linked hydrogels, providing a highly adaptable method of engineering injectable, rapidly gelling hydrogel networks for potential in vivo applications.
References
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Solution Properties of Poly(N-isopropylacrylamide)
M. Heskins,J. E. Guillet +1 more
TL;DR: In this paper, a lower critical solution temperature of poly(N-isopropyl acrylamide was found to be due to an entropy effect, which was attributed to the formation of nonpolar and intermolecular hydrogen bonds.
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Polymeric Systems for Controlled Drug Release
TL;DR: Kevin Shakesheff investigates new methods of engineering polymer surfaces and the application of these engineered materials in drug delivery and tissue engineering.
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Alginate hydrogels as synthetic extracellular matrix materials
TL;DR: Alginate may prove to be an ideal material with which to confer specific cellular interactive properties, potentially allowing for the control of long-term gene expression of cells within these matrices.
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Biodegradable block copolymers as injectable drug-delivery systems
TL;DR: The synthesis of a thermosensitive, biodegradable hydrogel consisting of blocks of poly(ethylene oxide) and poly(L-lactic acid) and aqueous solutions of these copolymers exhibit temperature-dependent reversible gel–sol transitions.