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Hydrogels for tissue engineering.
Kuen Yong Lee,David J. Mooney +1 more
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This article is published in Chemical Reviews.The article was published on 2001-05-31. It has received 4511 citations till now. The article focuses on the topics: Self-healing hydrogels.read more
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Injectable acellular hydrogels for cardiac repair.
TL;DR: Although the experimental findings completed to date in small animals are promising, future work needs to focus on the use of large animal models in clinically relevant scenarios and to elucidate the mechanisms of these injectable hydrogels to optimize their various properties.
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Self-assembly of small molecules affords multifunctional supramolecular hydrogels for topically treating simulated uranium wounds.
TL;DR: Two types of therapeutic agents, which have discrete yet complementary functions, self-assemble into nanofibers in water to formulate a new supramolecular hydrogel as a self-delivery biomaterial to reduce the toxicity of uranyl oxide at the wound sites.
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A new polymer/clay nano-composite hydrogel with improved response rate and tensile mechanical properties
TL;DR: In this paper, a new type of stimuli-responsive organic/inorganic nano-composite hydrogel was prepared by introducing fibrillar attapulgite into poly(2-hydroxyethyl methacrylate-co-poly(ethylene glycol) methyl ether methcarrylate co-methacrylic acid) network, which worked as the crosslinker instead of conventional chemical cross-linker.
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Stress–Strain Relationship of Highly Stretchable Dual Cross-Link Gels: Separability of Strain and Time Effect
TL;DR: In this article, the authors studied the stress-strain relation of dual cross-link gels having permanent cross-links and transient cross links over an unusually wide range of extension ratios and strain rates ϵ (or time t = (λ − 1)/ϵ).
Journal ArticleDOI
Hydrogels in ophthalmic applications.
TL;DR: Hydrogels are an extremely versatile class of materials with many potential applications in ophthalmology and their use as vitreous substitutes and intravitreal drug delivery systems is currently under investigation.
References
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Journal ArticleDOI
Solution Properties of Poly(N-isopropylacrylamide)
M. Heskins,J. E. Guillet +1 more
TL;DR: In this paper, a lower critical solution temperature of poly(N-isopropyl acrylamide was found to be due to an entropy effect, which was attributed to the formation of nonpolar and intermolecular hydrogen bonds.
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Polymeric Systems for Controlled Drug Release
TL;DR: Kevin Shakesheff investigates new methods of engineering polymer surfaces and the application of these engineered materials in drug delivery and tissue engineering.
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Alginate hydrogels as synthetic extracellular matrix materials
TL;DR: Alginate may prove to be an ideal material with which to confer specific cellular interactive properties, potentially allowing for the control of long-term gene expression of cells within these matrices.
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Biodegradable block copolymers as injectable drug-delivery systems
TL;DR: The synthesis of a thermosensitive, biodegradable hydrogel consisting of blocks of poly(ethylene oxide) and poly(L-lactic acid) and aqueous solutions of these copolymers exhibit temperature-dependent reversible gel–sol transitions.