Journal ArticleDOI
Hydrogels for tissue engineering.
Kuen Yong Lee,David J. Mooney +1 more
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This article is published in Chemical Reviews.The article was published on 2001-05-31. It has received 4511 citations till now. The article focuses on the topics: Self-healing hydrogels.read more
Citations
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Functional Human Vascular Network Generated in Photocrosslinkable Gelatin Methacrylate Hydrogels.
Ying-Chieh Chen,Ruei-Zeng Lin,Ruei-Zeng Lin,Hao Qi,Hao Qi,Yunzhi Yang,Yunzhi Yang,Hojae Bae,Hojae Bae,Juan M. Melero-Martin,Juan M. Melero-Martin,Ali Khademhosseini,Ali Khademhosseini,Ali Khademhosseini +13 more
TL;DR: The suitability of a photopolymerizable gelatin methacrylate (GelMA) hydrogel to support human progenitor cell‐based formation of vascular networks is demonstrated and it is shown that implantation of cell‐laden GelMA hydrogels into immunodeficient mice results in a rapid formation of functional anastomoses between the bioengineered human vascular network and the mouse vasculature.
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Controlling hydrogelation kinetics by peptide design for three-dimensional encapsulation and injectable delivery of cells
Lisa A. Haines-Butterick,Karthikan Rajagopal,Monica C. Branco,Daphne A. Salick,Ronak V. Rughani,Matthew Pilarz,Matthew S. Lamm,Darrin J. Pochan,Joel P. Schneider +8 more
TL;DR: A peptide-based hydrogelation strategy has been developed that allows homogenous encapsulation and subsequent delivery of C3H10t1/2 mesenchymal stem cells and gel/cell constructs stay fixed at the point of introduction, suggesting that these gels may be useful for the delivery of cells to target biological sites in tissue regeneration efforts.
Journal ArticleDOI
Rheological properties of peptide-based hydrogels for biomedical and other applications.
Congqi Yan,Darrin J. Pochan +1 more
TL;DR: This critical review covers the literature containing rheological characterization of the physical properties of peptide and polypeptide-based hydrogels including hydrogel bulk mechanical properties, gelation mechanisms, and the behavior ofhydrogels during and after flow.
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In Vivo Bio‐Safety Evaluations and Diagnostic/Therapeutic Applications of Chemically Designed Mesoporous Silica Nanoparticles
TL;DR: The critical issues and potential challenges related to the chemical design/synthesis of MSNs‐based “magic bullet” by advanced nano‐synthetic chemistry and in vivo evaluation have been discussed to highlight the issues scientists face in promoting the translation of MSN‐based DDSs into clinical trials.
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Skin-inspired hydrogel-elastomer hybrids with robust interfaces and functional microstructures
TL;DR: Zhao et al. as discussed by the authors proposed a simple yet versatile method to assemble hydrogels and elastomers into hybrids with extremely robust interfaces (interfacial toughness over 1,000 Jm−2) and functional microstructures such as microfluidic channels and electrical circuits.
References
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Journal ArticleDOI
Solution Properties of Poly(N-isopropylacrylamide)
M. Heskins,J. E. Guillet +1 more
TL;DR: In this paper, a lower critical solution temperature of poly(N-isopropyl acrylamide was found to be due to an entropy effect, which was attributed to the formation of nonpolar and intermolecular hydrogen bonds.
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Polymeric Systems for Controlled Drug Release
TL;DR: Kevin Shakesheff investigates new methods of engineering polymer surfaces and the application of these engineered materials in drug delivery and tissue engineering.
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Alginate hydrogels as synthetic extracellular matrix materials
TL;DR: Alginate may prove to be an ideal material with which to confer specific cellular interactive properties, potentially allowing for the control of long-term gene expression of cells within these matrices.
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Biodegradable block copolymers as injectable drug-delivery systems
TL;DR: The synthesis of a thermosensitive, biodegradable hydrogel consisting of blocks of poly(ethylene oxide) and poly(L-lactic acid) and aqueous solutions of these copolymers exhibit temperature-dependent reversible gel–sol transitions.