Journal ArticleDOI
Hydrogels for tissue engineering.
Kuen Yong Lee,David J. Mooney +1 more
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This article is published in Chemical Reviews.The article was published on 2001-05-31. It has received 4511 citations till now. The article focuses on the topics: Self-healing hydrogels.read more
Citations
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Alginate: properties and biomedical applications
Kuen Yong Lee,David J. Mooney +1 more
TL;DR: This review will provide a comprehensive overview of general properties of alginate and its hydrogels, their biomedical applications, and suggest new perspectives for future studies with these polymers.
Journal ArticleDOI
Hydrogels for biomedical applications.
TL;DR: The composition and synthesis of hydrogels, the character of their absorbed water, and permeation of solutes within their swollen matrices are reviewed to identify the most important properties relevant to their biomedical applications.
Journal ArticleDOI
Hydrogels for tissue engineering: scaffold design variables and applications.
Jeanie L. Drury,David J. Mooney +1 more
TL;DR: Hydrogels are an appealing scaffold material because they are structurally similar to the extracellular matrix of many tissues, can often be processed under relatively mild conditions, and may be delivered in a minimally invasive manner.
Journal ArticleDOI
Highly stretchable and tough hydrogels
Jeong-Yun Sun,Xuanhe Zhao,Widusha R. K. Illeperuma,Ovijit Chaudhuri,Kyu Hwan Oh,David J. Mooney,David J. Mooney,Joost J. Vlassak,Zhigang Suo +8 more
TL;DR: The synthesis of hydrogels from polymers forming ionically and covalently crosslinked networks is reported, finding that these gels’ toughness is attributed to the synergy of two mechanisms: crack bridging by the network of covalent crosslinks, and hysteresis by unzipping thenetwork of ionic crosslinks.
References
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Journal ArticleDOI
Controlled growth factor release from synthetic extracellular matrices.
TL;DR: A model delivery system that can respond to mechanical signalling and upregulate the release of a growth factor to promote blood vessel formation is reported, which may find a number of applications, including regeneration and engineering of new tissues and more general drug-delivery applications.
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Review: Hydrogels for cell immobilization.
TL;DR: This review surveys the current developments in immobilization of mammalian cells in hydrogels and discusses hydrogel requirements for use in adhesion, matrix entrapment, and microencapsulation, the respective processing methods, as well as current applications.
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Cyclic mechanical strain regulates the development of engineered smooth muscle tissue
TL;DR: It is shown that the appropriate combinations of mechanical stimuli and polymeric scaffolds can enhance the mechanical properties of engineered tissues and upregulated elastin and collagen gene expression and led to increased organization in tissues.
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Biodegradable Polymers for Protein and Peptide Drug Delivery
Wayne R. Gombotz,Dean K. Pettit +1 more
TL;DR: A large cross-section of degradable polymeric delivery systems for protein and peptide pharmaceuticals, including monolithic type devices in which the drug is dispersed throughout the polymer and protein-polymer conjugates, are reviewed.
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Fibrin gel as a three dimensional matrix in cardiovascular tissue engineering
Qing Ye,Gregor Zünd,Peter Benedikt,Stefan Jockenhoevel,Simon P. Hoerstrup,Shelly Sakyama,Jeffrey A. Hubbell,Marko Turina +7 more
TL;DR: A three-dimensional fibrin gel structure can serve as a useful scaffold for tissue engineering with controlled degradation, excellent seeding effects and good tissue development.