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Hydrogels for tissue engineering.
Kuen Yong Lee,David J. Mooney +1 more
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This article is published in Chemical Reviews.The article was published on 2001-05-31. It has received 4511 citations till now. The article focuses on the topics: Self-healing hydrogels.read more
Citations
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Spatiotemporally Controllable and Cytocompatible Approach Builds 3D Cell Culture Matrix by Photo‐Uncaged‐Thiol Michael Addition Reaction
TL;DR: A new concept of photocrosslinking mechanism is demonstrated, in which light controls where and when thiol-Michael addition occurs in 3D and light dose controls gel stiffness, thus providing a unique approach particularly suitable for fabricating 3D cell-culture matrix.
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Composite chitosan hydrogels for extended release of hydrophobic drugs
TL;DR: For the first time that oil in water microemulsions were introduced into a chitosan hydrogels for the creation of a hydrophobic drug delivery system, as confirmed by Fourier transform infrared spectroscopy experiments.
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Controlling the kinetics of thiol-maleimide Michael-type addition gelation kinetics for the generation of homogenous poly(ethylene glycol) hydrogels.
TL;DR: Although fast Michael-type addition crosslinked hydrogels appear uniform by bulk modulus readings and visual inspection, they are non-uniform in the micron scale, with high and low crosslinking regions that result in differences in cellular behavior.
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Hybrid polymer and low molecular weight gels – dynamic two-component soft materials with both responsive and robust nanoscale networks
TL;DR: In this article, a low molecular weight gelator (LMWG, 1,3:2,4-dibenzylidene-D-sorbitol-p,p′-dicarboxylic acid) and a polymer gelator were combined to obtain a self-sorting multi-gelator gels.
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Hydrogels as scaffolds and delivery systems to enhance axonal regeneration after injuries.
TL;DR: Providing a permissive substrate for axonal regeneration in combination with delivery systems for the release of molecules, which enhances axonal growth, could increase regeneration and the recovery of functions in the CNS or the PNS.
References
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Journal ArticleDOI
Solution Properties of Poly(N-isopropylacrylamide)
M. Heskins,J. E. Guillet +1 more
TL;DR: In this paper, a lower critical solution temperature of poly(N-isopropyl acrylamide was found to be due to an entropy effect, which was attributed to the formation of nonpolar and intermolecular hydrogen bonds.
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Polymeric Systems for Controlled Drug Release
TL;DR: Kevin Shakesheff investigates new methods of engineering polymer surfaces and the application of these engineered materials in drug delivery and tissue engineering.
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Alginate hydrogels as synthetic extracellular matrix materials
TL;DR: Alginate may prove to be an ideal material with which to confer specific cellular interactive properties, potentially allowing for the control of long-term gene expression of cells within these matrices.
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Biodegradable block copolymers as injectable drug-delivery systems
TL;DR: The synthesis of a thermosensitive, biodegradable hydrogel consisting of blocks of poly(ethylene oxide) and poly(L-lactic acid) and aqueous solutions of these copolymers exhibit temperature-dependent reversible gel–sol transitions.